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中山醫 生醫系

張文瑋 教授

Dr. Wen-Wei Chang


Tel:(04)2473-0022 ext 12305 (Office);
11701 (Lab)



  • 2006.05 博士 國立成功大學基礎醫學研究所 病毒免疫學
  • 1999.06 學士 國立成功大學 生物學系



  • 2017.08 ~ present  中山醫學大學 生物醫學科學學系 教授兼系主任
  • 2015.08 ~ 2017.07 中山醫學大學 生物醫學科學學系 教授
  • 2012.08 ~ 2015.07 中山醫學大學 生物醫學科學學系 副教授
  • 2009.08 ~ 2012.07 中山醫學大學 生物醫學科學學系 助理教授
  • 2006.07 ~ 2009.07 中央研究院 基因體研究中心 博士後研究員
  • 1999.09 ~ 2006.05 成功大學醫學院 基礎醫學研究所 博士生研究助理



  • 腫瘤生物學
  • 免疫學
  • 細胞生物學



本實驗室研究方向著重於癌症幹細胞的生物學,以乳癌及口腔癌為對象,試圖了解調控癌症幹細胞的訊息傳遞網路。另外,也試圖從天然萃取物中尋找能夠抑制癌症幹細胞的潛力分子,並了解其作用機轉。近年來也開始進行產學合作,主要協助廠商進行產品抗菌功效測試及調節免疫功能測試。 過去與目前正在進行的研究計畫
  1. 98年度國科會計畫. 熱休克蛋白在乳癌幹細胞的生物性功能角色探討. (NSC-98-2314-B-040-023)
  2. 99年度國科會大專生專題研究計畫. 張毓尹. 熱休克蛋白90抑制劑對乳癌幹細胞致癌性的影響. (指導教授) (NSC-99-2815-C-040-001-B)
  3. 100年度國科會計畫. 熱休克蛋白27與其客戶蛋白在乳癌幹細胞的角色.(主持人) (NSC-100-2314-B-040-013)
  4. 100年度國科會計畫(提升私校研發能量專案計畫,整合型). 口腔癌前病變及口腔癌之預防、治療及致病機轉之探討--口腔癌前病變及口腔癌之預防、治療及致病機轉之探討. (共同主持人) (NSC-100-2632-B-040-001-MY3)
  5. 101年度科技部計畫. 乳癌幹細胞的新血管生成潛力研究.(主持人) (NSC101-2314-B-040-015-MY2)
  6. 103年度科技部計畫. 熱休克蛋白27與其磷酸化對於乳癌幹細胞之維持的影響. (主持人) (MOST 103-2314-B-040-015-MY3)
  7. 104年度科技部計畫  黴菌毒素之單株及單鏈抗體生產及快速檢測多重毒素之免疫奈米試紙開發(3-2)
  8. 105年度科技部計畫  熱休克蛋白27與其磷酸化對於乳癌幹細胞之維持的影響(3-3)
  9. 106年度科技部計畫  免疫檢查哨分子在癌幹細胞之非免疫調節活性的功能性探討
  10. 106年度 產學計畫  益生菌(Lactobacillus reuteri ADR-1 及ADR-3)改善二型糖尿病之相關研究及功效資料整理   



  1. Chen SM, Wang BY, Lee CH, Lee HT, Li JJ, Hong GC, Hung YC, Chien PJ, Chang CY, Hsu LS, Chang WW. Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells. Oncotarget. 2017;8(44):76057-76068.
  2. Chang YC, Lin CW, Yu CC, Wang BY, Huang YH, Hsieh YC, Kuo YL, Chang WW. Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression. Oncotarget. 2016 ;7(11):12137-49.
  3. Lee YC, Yu CC, Lan C, Lee CH, Lee HT, Kuo YL, Wang PH, Chang WW. Plasminogen activator inhibitor-1 as regulator of tumor-initiating cell properties in head and neck cancers. Head Neck. 2016;38 Suppl 1:E895-904.
  4. Wang BY, Liao ML, Hong GC, Chang WW, Chu CC. Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles. Nanomaterials (Basel). 2017;7(9). pii: E269.
  5. Lu KT, Wang BY, Chi WY, Chang-Chien J, Yang JJ, Lee HT, Tzeng YM, Chang WW. Ovatodiolide Inhibits Breast Cancer Stem/Progenitor Cells through SMURF2-Mediated Downregulation of Hsp27. Toxins (Basel). 2016;8(5). pii: E127.
  6. Lee CH, Yu CC, Wang BY, Chang WW. Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs. Oncotarget. 2016 Jan 12;7(2):1215-26. doi: 10.18632/oncotarget.6261. Review. PubMed PMID: 26527320; PubMed Central PMCID: PMC4811455.
  7. Lee YC, Chang WW, Chen YY, Tsai YH, Chou YH, Tseng HC, Chen HL, Wu CC, Chang-Chien J, Lee HT, Yang HF, Wang BY. Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2. Int J Mol Sci. 2017;18(9). pii: E1986.
  8. Chang YC, Tsai CH, Lai YL, Yu CC, Chi WY, Li JJ, Chang WW,(2014), Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1. Journal of Cellular and Molecular Medicine. 18, 698-708. (IF=3.698, R/C= 27/122 in Medicine, Research & Experimental )
  9. Chang WW, Lai CH, Chen MC, Liu CF, Kuan YD, Lin ST, Lee CH,(2013), Salmonella enhance chemosensitivity in tumor through connexin 43 upregulation. International Journal of Cancer. 133, 1926-1935. (IF=5.007, R/C = 34/202 in Oncology)
  10. Chang WW, Lin RJ, Yu J, Chang WY, Fu CH, Lai ACY, Yu JC, Yu AL.,(2013), The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors. Breast Cancer Research. 15, 39-55. (IF=5.881, R/C = 25/202 in Oncology)
  11. Lee CH, Wu YT, Hsieh HC, Yu Y, Yu AL, Chang WW,(2014), Epidermal growth factor/heat shock protein 27 pathway regulates vasculogenic mimicry activity of breast cancer stem/progenitor cells. Biochimie. 104, 117-126. (IF=3.123, R/C = 122/291 in Biochemistry & Molecular Biology)
  12. Fu CH, Lin RJ, Yu J, Chang WW, Liao GS, Chang WY, Tseng LM,Tsai YF, Yu JC, Yu AL,(2014), A Novel Oncogenic Role of Inositol Phosphatase SHIP2 in ER-Negative Breast Cancer Stem Cells: Involvement of JNK/Vimentin Activation. Stem Cells. 32, 2048-2060. (IF=7.133, R/C = 4/68 in Hematology)
  13. Chang WW, Hu FW, Yu CC, Wang HH, Feng HP, Lan C, Tsai LL, Chang YC. 2013. Quercetin Eliminates Tumor Initiating Stem-Like and Mesenchymal Transformation Property in Head and Neck Cancer. Head&Neck. 35(3):413-9. (First author, IF=3.006, R/C= 1/44 in Otorhinolaryngology)
  14. Lee CH, Hong HM, Chang YY, Chang WW. Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie. 2012. 94(6):1382-9. (Corresponding author, IF=3.123, R/C=122/291 in Biochemistry & Molecular Biology)
  15. Chen SM, Tsai YS, Lee SW, Liu YH, Liao SK, Chang WW, Tsai PJ.,(2014), Astragalus membranaceus modulates the Th1/2 immune balance and activates PPARγ in a murine asthma model. Biochemistry and Cell Biology. 92, 397-405. (Co-corresponding author. IF=2.35, R/C = 182/291 in Biochemistry & Molecular Biology)
  16. Chang WW, Lee CH,(2014), Salmonella as An Innovative Therapeutic Antitumor Agent. International Journal of Molecular Sciences. 15(8):14546-54. Review. (IF=2.339, R/C = 52/148 in Chemistry, Multidisciplinary)
  17. Hung CH, Chang WW, Liu SC, Wu SJ, Chu CC, Tsai YJ, Imae T.,(2015), Self-aggregation of amphiphilic [60]fullerenyl focal point functionalized PAMAM dendrons into pseudodendrimers: DNA binding involving dendriplex formation. Journal of Biomedical Materials Research Part A. 103(5):1595-604. ( IF=2.841, R/C = 18/77 in Engineering Biomedical)
  18. Peng CY, Fong PC, Yu CC, Tsai WC, Tzeng YM, Chang WW,(2013), Methyl Antcinate A Suppresses the Population of Cancer Stem-Like Cells in MCF7 Human Breast Cancer Cell Line. Molecules. 18, 2539-2548. (IF=2.095, R/C = 30/58 in Chemistry, Organic)
  19. Chang WW, Kuan YD, Chen MC, Lin ST, Lee CH.,(2012), Tracking of mouse breast cancer stem-like cells with Salmonella. Experimental Biology and Medicine. 237, 1189-1196. (IF=2.226, R/C= 61/124 in Medicine, Research & Experimental)
  20. Lee CH, Lin ST, Liu JJ, Chang WW, Hsieh JL, Wang WK.,(2013), Salmonella induce autophagy in melanoma by downregulation AKT/mTOR pathway. Gene Therapy. 3, 309-316. (IF=4.196, R/C = 25/165 in Biotechnology & Applied Microbiology)
  21. Kast RE, Boockvar JA, Brüning A, Cappello F, Chang WW, et al.,(2013), A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care. Oncotarget. 4, 502-530. (IF=6.63, R/C = 17/203 in Oncology)
  22. Cheng YJ, Chang MY, Chang WW, Wang WK, Liu CF, Lin ST, Lee CH,(2014), Resveratrol enhances chemosensitivity in mouse melanoma model through connexin 43 upregulation. Environmental Toxicology. (accepted. IF=2.562, R/C = 14/81 in Water Resources)
  23. Wang WK, Lin ST, Chang WW, Liu LW, Li TY, Kuo CY, Hsieh JL, Lee CH,(2014), Hinokitiol induces autophagy in murine breast and colorectal cancer cells. Environmental Toxicology. (accepted. IF=2.562, R/C = 14/81 in Water Resources)
  24. Tu DG, Yu Y, Lee CH, Kuo YL, Lu YC, Tu CW, ChangWW. 2015. Hinokitiol inhibits vasculogenic mimicry activity of breast cancer stem/prgenitor cells through proteasome-mediated degradation of epidermal growth factor receptor. Oncology Letters. (accepted. IF=0.987, R/C=183/203 in Oncology)



  • Lan C, Yu CC, Chang YC, Chang WW. The role of plasminogen activator inhibitor-1 in oral cancer stem cells. The 27th Joint Annual Conference of Biomedical Sciences. 2012. Taipei, Taiwan. (Poster Presentation, No. 010).
  • Lai YL, Yu CC, Chang YC, Chang WW. The role of arecoline in the myofibroblast differentiation from normal oral fibroblasts and keratinocytes. The 8th Asia Pacific Symosium on Neural Regeration in conjunction with The 5th Pan Pacific Symposium on Stem Cells and Cancer Research. 2012. Taipei, Taiwan (Poster Presentation, No. PG-3)
  • Chang WW, Lee CH, Hong HM, Chang YY. Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. 22nd Biennial Congress of the European Association for Cancer Research. 2012. Barcelona. Spain. (Poster Presentation, No. 112)
  • Lee CH, Wu YT, Hsieh HC, Yu Y, Yu AL, Chang WW. Epidermal growth factor/heat shock protein 27 pathway regulates vasculogenic mimicry activity of breast cancer stem-like/progenitor cells. The 18th International Vascular Biology Meeting. 2014. Kyoto. Japan. (Poster Presentation, No. LB-15).
  • Chang WW, Chang-Chien J, Yang JJ, Tzang BS, Hsu TC. Influences of zebrafish embryo development by human parvovirus B19- NS1 and VP1u protein. 7th Zebrafish Disease Models Conference. 2014. Madison. USA. (Poster Presentation, No. 135)