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Wen-Wei Chang ( Professor, Ph. D.)

Wen-Wei Chang

(Professor; Ph. D)


Tel(Office):886-4-2473-0022 ext 12317
Tel(Lab):886-4-2473-0022 ext 11474


Interests in Research

Cancer stem cells (CSCs) are a particular sub-population of cells within cancers/tumors. CSCs have been demonstrated to be associated with tumor initiation, chemoresistance, radioresistance and metastasis of cancers. To target CSCs is an emerging research area in cancer research and cancer therapy. Our interests are focus on the signal transduction of maintenance pathways, such as epithelial-mesenchymal transition, nuclear factor kappa B, Wnt/beta-catenin or p53, in CSCs of breast cancer and oral squamous carcinoma cells. We are recently working on the involvement of heat shock proteins (HSPs) in the maintenance CSCs, Hsp27 and Hsp90 in particular. We also interest in searching CSC-targeting natural compounds, such as plant phytochemicals or Chinese herb extracts, and study their molecular mechanisms.

Publications (at most 7 publications in recent 5 years)

  • Chang YC, Tsai CH, Lai YL, Yu CC, Chi WY, Li JJ, Chang WW,(2014), Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1. Journal of Cellular and Molecular Medicine. 18, 698-708. (IF=3.698, R/C= 27/122 in Medicine, Research & Experimental ).

  • Lee CH, Wu YT, Hsieh HC, Yu Y, Yu AL, Chang WW,(2014), Epidermal growth factor/heat shock protein 27 pathway regulates vasculogenic mimicry activity of breast cancer stem/progenitor cells. Biochimie. 104, 117-126. (IF=3.123, R/C = 122/291 in Biochemistry & Molecular Biology)

  • Fu CH, Lin RJ, Yu J, Chang WW, Liao GS, Chang WY, Tseng LM,Tsai YF, Yu JC, Yu AL,(2014), A Novel Oncogenic Role of Inositol Phosphatase SHIP2 in ER-Negative Breast Cancer Stem Cells: Involvement of JNK/Vimentin Activation. Stem Cells. 32, 2048-2060. (IF=7.133, R/C = 4/68 in Hematology)

  • Chang WW, Lai CH, Chen MC, Liu CF, Kuan YD, Lin ST, Lee CH,(2013), Salmonella enhance chemosensitivity in tumor through connexin 43 upregulation. International Journal of Cancer. 133, 1926-1935. (IF=5.007, R/C = 34/202 in Oncology)

  • Chang WW, Lin RJ, Yu J, Chang WY, Fu CH, Lai ACY, Yu JC, Yu AL.,(2013), The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors. Breast Cancer Research. 15, 39-55. (IF=5.881, R/C = 25/202 in Oncology)

  • Chang WW, Hu FW, Yu CC, Wang HH, Feng HP, Lan C, Tsai LL, Chang YC. 2013. Quercetin Eliminates Tumor Initiating Stem-Like and Mesenchymal Transformation Property in Head and Neck Cancer. Head&Neck. 35(3):413-9. (First author, IF=3.006, R/C= 1/44 in Otorhinolaryngology)

  • Lee CH, Hong HM, Chang YY, Chang WW. Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. Biochimie. 2012. 94(6):1382-9. (Corresponding author, IF=3.123, R/C=122/291 in Biochemistry & Molecular Biology)