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Wen-Wei Chang

Wen-Wei Chang

(Professor; Ph. D)


Tel(Office):886-4-2473-0022 ext 12305
Tel(Lab):886-4-2473-0022 ext 11701


Interests in Research

Cancer stem cells (CSCs) are a particular sub-population of cells within cancers/tumors. CSCs have been demonstrated to be associated with tumor initiation, chemoresistance, radioresistance and metastasis of cancers. To target CSCs is an emerging research area in cancer research and cancer therapy. Our interests are focus on the signal transduction of maintenance pathways, such as epithelial-mesenchymal transition, nuclear factor kappa B, Wnt/beta-catenin or p53, in CSCs of breast cancer and oral squamous carcinoma cells. We are recently working on the involvement of heat shock proteins (HSPs) in the maintenance CSCs, Hsp27 and Hsp90 in particular. We also interest in searching CSC-targeting natural compounds, such as plant phytochemicals or Chinese herb extracts, and study their molecular mechanisms.

Publications (at most 7 publications in recent 5 years)

  1. Chen SM, Wang BY, Lee CH, Lee HT, Li JJ, Hong GC, Hung YC, Chien PJ, Chang CY, Hsu LS, Chang WW. Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells. Oncotarget. 2017;8(44):76057-76068.
  2. Chang YC, Lin CW, Yu CC, Wang BY, Huang YH, Hsieh YC, Kuo YL, Chang WW. Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression. Oncotarget. 2016 ;7(11):12137-49.
  3. Lee YC, Yu CC, Lan C, Lee CH, Lee HT, Kuo YL, Wang PH, Chang WW. Plasminogen activator inhibitor-1 as regulator of tumor-initiating cell properties in head and neck cancers. Head Neck. 2016;38 Suppl 1:E895-904.
  4. Wang BY, Liao ML, Hong GC, Chang WW, Chu CC. Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles. Nanomaterials (Basel). 2017;7(9). pii: E269.
  5. Lu KT, Wang BY, Chi WY, Chang-Chien J, Yang JJ, Lee HT, Tzeng YM, Chang WW. Ovatodiolide Inhibits Breast Cancer Stem/Progenitor Cells through SMURF2-Mediated Downregulation of Hsp27. Toxins (Basel). 2016;8(5). pii: E127.
  6. Lee CH, Yu CC, Wang BY, Chang WW. Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs. Oncotarget. 2016 Jan 12;7(2):1215-26. doi: 10.18632/oncotarget.6261. Review. PubMed PMID: 26527320; PubMed Central PMCID: PMC4811455.
  7. Lee YC, Chang WW, Chen YY, Tsai YH, Chou YH, Tseng HC, Chen HL, Wu CC, Chang-Chien J, Lee HT, Yang HF, Wang BY. Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2. Int J Mol Sci. 2017;18(9). pii: E1986.