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Yu-Fan Liu (Professor, Ph. D.)

Yu-Fan Liu

(Professor; Ph. D)


Tel(Office):886-4-2473-0022 ext 11819



  • 1998-2005 Institute of Biochemistry National Yang-Ming University, Taiwan. Degree awarded: Ph.D.
  • 1991-1993 Institute of Biochemistry National Taiwan University, Taiwan. Degree awarded: M.Sc.
  • 1987-1991 Department of Agricultural Chemistry, National Taiwan University, Taiwan. Degree awarded: B.Sc.
Professional and Academic Experiences
  • 2011-present Associated Professor, Department of Biomedical Science, Chung Shan Medical University, Taiwan
  • 2006-2011 Assistant professor, Department of Biomedical Science, Chung Shan Medical University, Taiwan
  • 2003-2006 Adjunct assistant professor, Department of Biotechnology Ming-Chuan University, Taiwan
  • 2003-2006 Project Investigator, TaiGen Biotechnology Company, Taiwan
  • 1995-1998 Associate Research Scientist, National Center for High-Performance Computing, Taiwan
Publications (at most 30 publications in recent 5 years
  1. Lin C.W., Chou Y.E., Yeh C.M., Yang S.F. Chuang C.Y. Y.F. Liu*. A functional variant at the miRNA binding site in HMGB1 gene is associated with risk of oral squamous cell carcinoma. Oncotarget 8: 34630-34642 (2017)

  2. Sheu M.J., Hsieh, M.J., Chou Y.E., Wang P.H., Yeh C.B., Yang S.F., Lee H.L. Lee, Y.F. Liu*. Effects of ADAMTS14 genetic polymorphism and cigarette smoking on the clinicopathologic development of hepatocellular carcinoma. PLoS ONE 12, e0172506 (2017)

  3. Huang, S.W., Lin, H.Y., Yeh, C.B., Chen, L.Y., Chou, Y.E., Yang, S.F., Y.F. Liu*. Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms with Hepatocellular Carcinoma in Taiwan. Int. J Med. Sci. 14: 136-142 (2017).

  4. Su, S.C., Lin, C.W., Y.F. Liu, W.L., F., M.K., C., C.P., Y., Yang, W.E., Su, C.W., C.Y., C., Li, W.H., et al. Exome Sequencing of Oral Squamous Cell Carcinoma Reveals Molecular Subgroups and Novel Therapeutic Opportunities. Theranostics 7: 1088-1099 (2017).

  5. Tsai H.T., Hsieh, M.J., Lin C.W., Su S.C., Miao N.F., Yang S.F., Huang H.C., Fu-Chih Lai, Y.F. Liu*. Combinations of SERPINB5 gene polymorphisms and environmental factors are associated with oral cancer risks. PLoS ONE 12(3): e0163369 (2017).

  6. Cheng, H.L.# Y.F. Liu#, Su, C.W., Su, S.C., Chen, M.K., Yang, S.F., and Lin, C.W.*. Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk. Oncotarget 7: 69384-63696 (2016).

  7. Yang SF, Yeh CB, Chou YE, Lee HL, Y.F. Liu*. Serpin peptidase inhibitor (SERPINB5) haplotypes are associated with susceptibility to hepatocellular carcinoma. Sci Rep. 6: 26605 (2016).

  8. Wang B, Yeh CB, Lein MF, Su CM, Yang SF, Y.F. Liu*, et al. Effects of HMGB1 Polymorphisms on the Susceptibility and Progression of Hepatocellular Carcinoma. Int J Med Sci. 13(4):304-9 (2016).

  9. Sun YH, Yang SF, Y.F. Liu, Ko JL, Wu CH, Wu TF, et al. Single-Nucleotide Polymorphisms and Haplotypes of Intercellular Adhesion Molecule-1 in Uterine Cervical Carcinogenesis in Taiwanese Women. Reproductive sciences. 23(3):401-8 (2016).

  10. Su SC, Hsieh MJ, Y.F. Liu, Chou YE, Lin CW, Yang SF. ADAMTS14 Gene Polymorphism and Environmental Risk in the Development of Oral Cancer. PloS one. 11(7):e0159585 (2016).

  11. Y.F. Liu, Chiang SL, Lin CY, Chang JG, Chung CM, Ko AM, et al. Somatic Mutations and Genetic Variants of NOTCH1 in Head and Neck Squamous Cell Carcinoma Occurrence and Development. Sci Rep. 6: 24014 (2016).

  12. Liao, C. T., Y.F. Liu, Chiang, Y. C., Lo, H. H., Du, S. C., Hsu, P. C., and Hsiao, Y. M.: Functional characterization and transcriptome analysis reveal multiple roles for prc in the pathogenicity of the black rot pathogen Xanthomonas campestris pv. campestris, Research in microbiology, 167, 299-312 (2016).

  13. Lee, C. P., Chiang, S. L., Ko, A. M., Y.F. Liu, Ma, C., Lu, C. Y., Huang, C. M., Chang, J. G., Kuo, T. M., Chen, C. L., Tsai, E. M., and Ko, Y. C.: ALPK1 phosphorylates myosin IIA modulating TNF-alpha trafficking in gout flares, Sci Rep, 6, 25740 (2016).

  14. Chou CH, Ueng KC, Y.F. Liu, Wu CH, Yang SF, Wang PH. Impact of Intercellular Adhesion Molecule-1 Genetic Polymorphisms on Coronary Artery Disease Susceptibility in Taiwanese Subjects. Int J Med Sci. 12(6):510-6 (2016).

  15. C.Y. Lin, Y.F. Liu and Y.C. Tsai (2015) “Differential Effects on Fibroblast Cells Proliferation and Migration by Bismuth Subgallate and Borneol Individual and Combination” International Journal of Pharmacology 11(3) : 236-242

  16. Y.S. Lin, Y.F. Liu, Y.E. Chou, S.F. Yang, M.S. Chien, C.H. Wu, C.H. Chou, C.W. Cheng and P.H. Wang (2014) “Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms and Haplotypes with Uterine Cervical Cancer in Taiwanese Women” PLOS ONE 9(9) : e104038

  17. T.M. Kuo, S.Y. Luo, S.L. Chiang, C.P. Lee, Y.F. Liu, J.G. Chang, M.H. Tsai and Y.C. Ko (2014) “Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells.” J. Biomed Sci. 21: 93

  18. Y.C. Chang, Y.H. Chow, L.H. Sun, Y.F. Liu, Y.T. Lee, K.H. Lue and J.L. Ko (2014) “Alleviation of respiratory syncytial virus replication and inflammation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes” Antiviral Res. 110: 123-131

  19. Y.L. Lin, Y.J. Tsai, Y.F. Liu, C.M. Hung, Y.J. Lee, H. Pan and C. Li (2013) “The Critical Role of Protein Arginine Methyltransferase prmt8 in Zebrafish Embryonic and Neural Development Is Non-Redundant with Its Paralogue prmt1” PLOS ONE 8(3) : e55221

  20. M.H. Chien, Y.F. Liu, C.H. Hsin, C.H. Lin, C.H. Shih, S.F. Yang, C.W. Cheng and C.W. Lin (2013) “Impact of VEGF-C gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan” PLOS ONE 8(4) : e60283

  21. A.M. Ko, H.P. Tu, J.G. Chang, C.Y. You, S.L. Chiang, S.J. Chang, Y.F. Liu, A.M. Ko, C.H. Lee, C.M. Chang, S.F. Tsai and Y.C. Ko (2013) “ALPK1 genetic regulation and risk in relation to gout” Int. J. Epidemiol. 42(2): 466-474

  22. S.S. Wang#, Y.F.Liu#, Y.-C. Ou, C.S. Chen, J.R. Li and S.F. Yang (2013) “Impacts of CA9 Gene Polymorphisms on Urothelial Cell Carcinoma Susceptibility and Clinicopathologic Characteristics in Taiwan” PLOS ONE 8(12) : e82804

  23. Y.F. Liu, C.T. Liao, W.L. Song, P.C. Hsu and Y.M, Hsiao* (2013) “GsmR, a response regulator with a histidine-aspartate-related output domain in Xanthomonas campestris, is positively controlled by Clp and involved in cell motility and the expression of genes responsible for flagellum synthesis.” FEBS Journal 280 (1): 199-213

  24. C.C Su, Y.F. Liu, S.Y. Li, J.J. Yang* and Y.C. Yen (2012) “Mutations in the CYP1B1 gene may contribute to juvenile-onset open-angle glaucoma.” Eye 26(10), 1369-1377

  25. C.W. Cheng, Y.F. Liu, J.C. Yu, H.W. Wang, S.L. Ding, C.N. Hsiung, H.M. Hsu, P.E. Wu and C.Y. Shen (2012) “Prognostic Significance of cyclin D1, β-catenin, and MTA1 in Patients with Invasive Ductal Carcinoma of the Breast.” Ann Surg. Oncol. 19(13), 4129-4139

  26. Y.F. Liu, S.H. Chang, H.L. Sun, Y.C. Chang, K.H. Lue and J.L. Ko* (2012) “IFN-γ Induction on Carbohydrate Binding Module of Fungal Immunomodulatory Protein in Human Peripheral Mononuclear Cells.” Journal of Agricultural and Food Chemistry 60(19), 4914-4922

  27. Y.T. Tee, Y.F. Liu, J.T. Chang, S.F. Yang, S.C. Chen, P.H. Wang and C.L. Liao (2012) “Single-Nucleotide Polymorphisms and Haplotypes of Membrane Type 1-Matrix Metalloproteinase in Susceptibility and Clinical Significance of Squamous Cell Neoplasia of Uterine Cervix in Taiwan Women” Reproductive Sciences 19(9): 932-938 /li>

  28. C.H. Hu, Y.F. Liu, J.S. Yu, Y.Y. Ng, S.J. Chen, P.H. Su and J.Y. Chen (2012) “A MID1 gene mutation in a patient with Opitz G/BBB syndrome that altered the 3D structure of SPRY domain” American Journal of Medical Genetics 158A(4): 726-731

  29. P.H. Su, Y.F. Liu, J.S. Yu, J.Y. Chen, S.J. Chen and Y.J. Lai* (2012) “Facial asymmetry and clinical manifestations in patients with novel insertion of the TCOF1 gene.” Clinical Genetics 82(5): 460-645

  30. Y.M. Hsiao*, Y.F. Liu, P.Y. Lee, P.C. Hsu, S.Y. Tseng and Y.C. Pan (2011) “Functional characterization of copA gene encoding multicopper oxidase in Xanthomonas campestris pv. campestris.” Journal of Agricultural and Food Chemistry 59(17), 9290-9302

  31. T.Y. Chen, Y.C. Li, Y.F. Liu, C.M. Tsai, Y.H. Hsieh, C.W. Lin, S.F. Yang and C.J. Wang* (2011) “ Role of MMP14 gene polymorphisms in susceptibility and pathological development to hepatocellular carcinoma” Annals of Surgical Oncology 18(8), 2348-2356

  32. W.H. Wang, Y.F. Liu, C.C. Su, M.C. Su, S.Y. Li and J.J. Yang* (2011) “A novel missense mutation in the connexin30 causes nonsyndromic hearing loss.” PLoS One 6(6): e21473 – SCI

  33. S.C. Tang, M.F. Wu, R.H. Wong, Y.F. Liu, L.C. Tang, C.H. Lai, C.P. Hsu and J.L. Ko* (2011) “Epigenetic mechanisms for silence of Glutathione Stransferase M2 expression by hypermethylated Sp1 binding in lung cancer” Cancer 117(14), 3209-3221

  34. Y.M. Hsiao*, Y.F. Liu, M.C. Fang and W.L. Song (2011) “XCC2731, a GGDEF domain protein in Xanthomonas campestris, is involved in bacterial attachment and is positively regulated by Clp” Microbiological Research 166(7), 548-565

  35. Y.M. Hsiao*, Y.F. Liu, Y.L. Huang and P.Y. Lee (2011) “Transcription analysis of pmeA gene encoding a pectin methylesterase in Xanthomonas campestris pv. Campestris” – Research in Microbiology 162(3), 270-278

  36. P.H. Wang, Y.F. Liu, H.T. Tsai, Y.T. Tee, L.Y. Lin, Y.H. Hsieh and S.F. Yang* (2010) “Elevated Plasma Osteopontin Level is Associated With Pelvic Inflammatory Disease” Reproductive Sciences. 17(11): 1052-1058

  37. C.Y. Feng, P.H. Wang, H.T. Tsai, J.L. Ko, S.C. Chen, C.Y. Lin, C.P. Han, J.S. Yang, Y.F. Liu, L.Y. Lin and S.F. Yang* (2010) “Polymorphisms of Human Nonmetastatic Clone 23 Type 1 Gene and Neoplastic Lesions of Uterine Cervix” Reproductive Sciences 17(10): 886-893

  38. P.H. Wang, Y.C. Yi, H.T. Tsai, Y.T. Tee, J.L. Ko, C.P. Han, Y.F. Liu, L.Y. Lin and S.F. Yang* (2010) “Significant association of genetic polymorphism of human nonmetastatic clone 23 type 1 gene with an increased risk of endometrial cancer” Gynecologic Oncology 119(1): 70-75

  39. C.J. Weng, C.M. Tsai, Y.C. Chen, Y.H. Hsieh, C.W. Lin, Y.F. Liu, S.C. Su, M.K. Chen and S.F. Yang* (2010) “Evaluation of the association of urokinase plasminogen activator system genes polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma” Annals of Surgical Oncology 17(12): 3394-3401

  40. M.Y. Lan, Y.F. Liu, S.J. Lin, Y.F. and Chen, C.H*. (2010) "Cavernous Malformations of the Central Nervous System Combined with Vascular Cutaneous Lesions due to KRIT1 Mutation: A Case Report" Clinical Neurology and Neurosurgery 112(8) : 729-732

  41. M.Y. Lan, M.H. Fu, Y.F. Liu, Y.Y. Chang, J.S. Liu, C.H. Peng and S.S. Chen* (2010) “High frequency of ETFDH c.250G>A Mutation in Taiwanese Patients with Late-Onset Lipid Storage Myopathy” Clinical Genetics 78(6) : 565-569

  42. P.C. Hsiao, M.K. Chen, S.C. Su, K.C. Ueng, Y.C. Chen, Y.H. Hsieh, Y.F. Liu, H.T. Tsai, S.F. Yang* (2010) “Hypoxia Inducible Factor-1α Gene Polymorphism G1790A and Its Interaction with Tobacco and Alcohol Consumptions Increase Susceptibility to Hepatocellular Carcinoma” Journal of Surgical Oncology : 102(2) 163-169

  43. Y.M. Hsiao*, Y.F. Liu, M.C. Fang and Y.H. Tseng (2010) “Transcriptional Regulation and Molecular Characterization of manA Gene Encoding the Biofilm Dispersing Enzyme Mannan Endo-1,4-β- mannosidase in Xanthomonas campestris” Journal of Agricultural and Food Chemistry 58(3), 1653-1663

  44. C.J. Weng, Y.H. Hsieh, C.M. Tsai, Y.H. Chu, K.C. Ueng, Y.F. Liu, A. I Zavras, S.C. Su, Y.C. Chen, M.K. Chen, S.F. Yang* (2010) “Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma” Annals of Surgical Oncology 17(7)– 1808-1815

  45. M.Y. Lan, S.J. Lin, Y.F. Chen, C.H. and Y.F. Liu* (2009) “A novel missense mutation of the SMPD1 gene in a Taiwanese patient with type B Niemann–Pick disease.” Ann. Hematol. 88(7): 695-697, 2009

  46. Y.F. Liu, Liu, H.Y., Tu, L.C., Lin C.W., Hsiao, K.M. and Pan, H.* (2008) “Zebrafish muscleblind-like genes: Identification, structural features and expression.” Comparative Biochemistry and Physiology, Part B 151(1), 118-124

  47. Wang L.C., Hung W.T., Pan H., Chen K.Y., Wu Y.C., Y.F. Liu, Hsiao K.M.* (2008) “Growth-dependent effect of muscleblind knockdown on Caenorhabditis elegans.” Biochemical and biophysical research communications 366(3) : 705-709

  48. S. Yang, S.J. Chen, M.F. Hsu, J.D. Wu C. K. Tseng, Y. F. Liu, H.C. Chen, C.W. Kuo, and C.S. Wu (2006) “Synthesis, Crystal Structure, Structure-Activity Relationships, and Antiviral Activity of a Potent SARS Coronavirus 3CL Protease Inhibitor” J.Med.Chem. 49(16), 4971-4980

  49. Y. F. Liu and U. C. Yang* (2004) “SCAdb: A candidate gene database for spinocerebellar ataxia.” Bioinformatics 20(16): 2656-2661