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分類清單
潘惠錦
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潘惠錦 教授

Dr. Hui-Chin Pan


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Tel:(04)2473-0022 ext 11802;12322

Fax:(04)2324-8187

hp29@csmu.edu.tw

學經歷
學歷:
  • 1995 美國威斯康辛大學麥迪森分校 發育生物學 博士
  • 1989 台灣大學 生化科學研究所 碩士
  • 1987 台灣大學 農業化學系 學士
經歷:
  • 2008-2010 中山醫學大學 生物醫學科學學系 系主任
  • 2005-迄今 中山醫學大學 生物醫學科學學系 教授
  • 2004-2005 中山醫學大學 生物醫學科學學系 副教授
  • 2000-2004 中山醫學院 生命科學系 副教授
  • 1997-2000 中山醫學院 生命科學系 助理教授
  • 1995-1997 美國北卡大學 Lineberger癌症研究中心 博士後研究員
  • 1992-1995 美國威斯康辛大學 發育生物學系 博士生研究助理
  • 1989-1992 美國威斯康辛大學 人類癌症學系 博士生研究助理

研究方向及計畫
  • 2010/08/01至2011/07/31
    Muscleblind家族蛋白質的功能研究(3/3)(NSC 97-2320-B-040-013-MY3)
  • 2009/08/01至2010/07/31
    Muscleblind家族蛋白質的功能研究(2/3)(NSC 97-2320-B-040-013-MY3)
  • 2008/08/01至2009/07/31
    Muscleblind家族蛋白質的功能研究(1/3)(NSC 97-2320-B-040-013-MY3)
  • 2008/01/01至2008/12/31
    生物醫學科技人才培育先導型計劃(醫衛分子領域)
  • 2007/08/01至2008/07/31
    CAG重複序列在RNA引導之致病機轉扮演角色的探討(2/2) (NSC 96-2320-B-040-040-MY2)
  • 2006/08/01至2007/07/31
    CAG重複序列在RNA引導之致病機轉扮演角色的探討(1/2) (NSC 95-2320-B-040-040-MY2)
  • 2005/08/01至2006/07/31
    非轉譯區CAG三聯核酸重複序列擴增所引發的致病機制之研究 (NSC 94-2320-B-040-045)
  • 2004/08/01至2005/07/31
    (CAG)n三聯核酸重複序列之基因轉殖動物模式建立及研究 (NSC 93-2320-B-040-054)
  • 2003/08/01至2004/07/31
    (CAG)n三聯核酸重複序列之基因轉殖動物模式建立及研究 (NSC 92-2320-B-040-046)
  • 2002/08/01至2003/07/31
    (CAG)n三聯核酸重複序列之基因轉殖動物模式建立及研究 (NSC 91-2320-B-040-034)
  • 2001/08/01至2002/07/31
    P73基因的表達研究 (NSC 90-2320-B-040-034)
  • 2000/08/1至2001/07/31
    P73基因的表達研究 (1/2) (NSC 89-2320-B-040-063)
  • 1999/08/1至2000/07/31
    P73和P51在腫瘤發生及動物發育中扮演的角色 (NSC 89-2320-B-040-018)
  • 1998/08/1至1999/07/31
    E2F1在細胞增殖、細胞凋亡及腫瘤形成中扮演的角色 (NSC 88-2314-B-040-018)

專長及教授課程
  • 發育生物學
  • 普通生物學
  • 分子遺傳學
  • 基因轉殖專題討論
  • 基因與發育
研究著作
  1. 期刊論文
    1. H-N Chuang, K-M Hsiao, H-Y Chang, C-C Wu and H Pan*. 2014. The homeobox transcription factor Irxl1 negatively regulates MyoD expression and myoblast differentiation. FEBS J. 281: 2990–3003.

    2. Y-L Lin, Y-J Tsai, Y-F Liu, Y-C Cheng, C-M Hung, Y-J Lee, H Pan and C Li*. 2013. The critical role of protein arginine methyltransferase prmt8 in zebrafish early embryonic and neural development is non-redundant with its paralogue prmt1. PloS ONE. 8(3): e55221.

    3. J-K Yu#, H Pan#, S-M Huang*, N-L Huang, C-C Yao, K-M Hsiao, C-W Wu. 2013. Calcium content of different compositions gallstones and pathogenesis of calcium carbonate. Asian Journal of Surgery. 36(1):26-35.

    4. Tsai. Y-J, Pan H, Hung C-M, Hou P-T, Li Y-C, Lee Y-J, Shen Y-T, Wu T-T, Li C*. 2011. The predominant protein arginine methyltransferase PRMT1 is critical for zebrafish convergence and extension during gastrulation. FEBS J. 278:905-917.

    5. Pan H*, Lin Y-J, Li M-W, Chuang H-N and Chou C-C*. 2011. Aquatic toxicity assessment of single-walled carbon nanotubes using zebrafish embryos. J. Phys.: Conf. Ser. 304: 012026.

    6. Hsu R-J#, Hsiao K-M #, Lin M-J, Li C-Y, Wang L-C, Chen L-K, and Pan H*. 2011. Long tract of untranslated CAG repeats is deleterious in transgenic mice. Plos One 6 (1): e16417. (doi:10.1371/journal.pone.0016417)

    7. Wang L.-C.#, Chen K.-Y.#, Pan H.#, Wu C.-C., Chen P.-H., Liao Y.-T., Li C., Huang M.-L.,and Hsiao K.-M.* 2011. Muscleblind participates in RNA toxicity of expanded CAG and CUG repeats in Caenorhabditis elegans. Cell. Mol. Life Sci. 68:1255-1267. (#, equal contribution)

    8. S-M Huang, K-M Hsiao, H Pan*, C-C Yao , T-J Lai, L-Y Chen, C-W Wu, W-Y Lui. 2011. Overcoming the difficulties in the laparoscopic management of contracted gallbladders with gallstones – possible role of fundus-down approach. Surg. Endosc.25 (1): 284-291.

    9. S-M Huang, C-C Yao , K-M Hsiao, H Pan*, T-J Lai, S-D Huang. 2011. The pathophysiologic significance of gallbladder volume changes in gallstone diseases. World J. Gastroen. 16 (34): 4341-4347.

    10. S-M Huang, C-C Yao , Y-W Cheng, L-Y Chen, H Pan*, K-M Hsiao, M-D Yang, C-W Wu, W-Y Lui. 2010. Laparoscopic primary closure of common bile duct combined with percutaneous cholangiographic drainage for treating choledocholithiasis Am. Surgeon. 76(5):517-521.

    11. H-N Chuang, H-Y Cheng, K-M Hsiao, C-W Lin, M-L Lin and H Pan*. 2010. The zebrafish homeobox gene irxl1 is required for brain and pharyngeal arch morphogenesis. Dev. Dyn. Feb;239(2):639-50

    12. Liu Y-F, Liu H-Y, Tu L-C, Lin C-W, Hsiao K-M, and Pan H*. 2008. Zebrafish muscleblind-like genes: identification, structural features and expression. Comp. Biochem. Phys. B, 151: 118-124 (SCI)

    13. Wang L-C, Hung W-T, Pan H*, Chen K-Y, Wu Y-C, Liu Y-F, and Hsiao, K-M*. 2008. Growth-dependent effect of muscleblind knockdown on Caenorhabditis elegans. Biochem. Bioph. Res. Co. 366: 705-709 (SCI)

    14. Lin M-J, Huang R-Y, Pan H, and Hsiao K-M*. 2008. Functional studies of the effect of NO donor on hu ma n CLCN1 polymorphism/mutants expressed in Xenopus laevis oocytes. Biochem. Bioph. Res. Co. 365: 724-728. (SCI)

    15. Chen K-Y, Pan H, Lin M-J , Li Y-Y, Wang L-C, Wu Y-C, and Hsiao K-M. 2007. Length-dependent toxicity of untranslated CUG repeats on Caenorhabditis elegans. Biochem. Bioph. Res. Co. 352:774-779. (SCI)

    16. Lin M-J, You T-H, Pan H, and Hsiao K-M. 2006. Functional characterization of CLCN1 mutations in Taiwanese patients with myotonia congenita via heterologous expression. Biochem. Bioph. Res. Co. 351:1043-1047. (SCI)

    17. Jou S.-B., Chang L.-I., Pan H., Chen P.-R., and Hsiao K.-M. 2004. Novel CLCN-1 mutations in the Taiwanese patients with myotonia congenita. J. Neurol. 251: 666-670. (SCI) (NSC90-2320-B-040-025)

    18. Pan, H., Dung, H.-N., Hsu, H.-M., Hsaio, K.-M., Chen, L.-Y. 2003. Cloning and developmental expression of p73 cDNA in zebrafish. Biochem. Bioph. Res. Co. 307:395-400. (SCI) (NSC90-2320-B-040-063; -034)

    19. H siao, K.-M., Chen, S.-S., Li, S.-Y., Lin, H.-M., Chiang, S.-Y., Pan, H., Huang, C.-C., Kuo, H.-C., Jou, S.-B., Su, C.-C., Ro, L.-S., Liu, C.-S., Lo, M.-C., Chen, C.-M., and Lin, C.-C. 2003. Epidemiological and genetic studies of myotonic dystrophy type 1 in . Neuroepidemiology 22: 283-289. (SCI) (NSC89-2316-B-040-001)

    20. Pan, H., Liao, S.-J. , Lai, W.-Y., Lu, H.-C. and Hsiao, K.-M. 2002. Overexpression but lack of mutation and methylation of p73 in hepatocellular carcino ma . Acta Oncol. 41: 550-555. (SCI) (NSC89-2320-B-040-018)

    21. Pan, H., Li, Y.-Y., Li, T.-C., Tsai, W.-T., Li, S.-Y., and Hsiao, K.-M. 2002. Increased (CTG/CAG)n lengths in the myotonic dystrophy type 1and Machado-Joseph disease genes in idiopathic azoospermia patients. Hum. Reprod. 17:1578-1583. (SCI) (NSC89-2316-B-040-001)

    22. Pan, H., Lin, H.-M., Ku, W.-Y., Li, T.-C., Li, S.-Y., Lin, C.-C., and Hsiao, K.-M. 2001.Haplotype an aly sis of the myotonic dystrophy type 1 (DM1) locus in : implications for low pr eva lence and founder mutations of Taiwanese myotonic dystrophy type 1. Eu. J. Hum. Genet. 9: 638-641. (SCI) (NSC89-2320-B-040-068)

    23. Jou, S-B., Lin, H-M., Pan, H., Chiu, Y-L., Li, S-Y., and Hsiao, K-M. 2001. Delineation of CTG repeats and clinical features in a Taiwanese Myotonic Dystrophy family. Proc. Natl. Sci. Council, ROC. 25: 40-44. (NSC89-2320-B040-068)

    24. Tu L-C, Hsiao K-M, and Pan H. 2010. Functional studies of mbnl1 in early zebrafish development. 2010 Zebrafish Symposium. NHRI, Zhunan, Miaoli. P24.

    25. S-M Huang, Z-Y Guo, K-M Hsiao, P P Li , W-C Lin, K-C Tseng, C-C Yao, L-C Ho, H Pan, J-K Yu. 2010. Genetic analysis of the gpbar1 gene in the taiwanese population and its possible pathophysiological roles in cholesterol gallbladder stone formation. Annual Autumn Meeting and the 45th Scientific Meeting of the Taiwanese Association for Digestive Surgery..

    26. Huang SM, Yao CC, Ho LC, Hsiao KM, Pan H, Chau GY, Wu CW. 2009. The chemical and crystallographic studies on calcium carbonate gallstones and the possible etiologic significance of limy bile. Annual Autumn Meeting and the 44th Scientific Meeting of the Taiwanese Association for Digestive Surgery. Yue-Cheng Research Building B1, I- Shou Univesity, . (*傑出優秀海報論文獎)

    27. Huang SM, Yao CC, Hsiao KM, Pan H, Chau GY, Wu CW. 2009. The possible roles fatty acids play in the pathogenesis of intrahepatic stone. Annual Autumn Meeting and the 44th Scientific Meeting of the Taiwanese Association for Digestive Surgery. Yue-Cheng Research Building B1, I-Shou Univesity, Kao-Hsiung, .

    28. H Pan, H-N Chuang, H-Y Cheng, C-C Wu. 2009. Irxl1 is a novel homeobox gene involved in brain, muscle and pharyngeal arch development in zebrafish. 6th European Zebrafish Genetics and Development Meeting, Rome, . Page149, P78.

    29. K-M Hsiao, L-C Tu, C-W Lin and H Pan. 2009. Functional studies of muscleblind proteins in early zebrafish development. 6th European Zebrafish Genetics and Development Meeting, Rome, . Page150, P79.

    30. H-N Chuang, C-C Wu, and H Pan. 2009. Investigation of zebrafish Irxl1 in the regulation of pharyngeal arch and muscle development. The 24th Joint Annual Conference of Biomedical Sciences () page289, P562.

    31. C-W Lin, and H Pan. 2009. Identification and functional an anlysis  of zebrafish mbnl3. The 24th Joint Annual Conference of Biomedical Sciences () page288, P558.

    32. L-C Wang, H. Pan, W-T H and K-M Hsiao. 2008. Developmentally-regulated effect of different expansion levels of CUG repeats is mediated by distinct RNA-binding proteins. The 23rd Joint Annual Conference of Biomedical Sciences (Taiwan) page158, P162. (*優秀壁報論文獎)

    33. C.-C. Lin, L.-K. C, and H. Pan. 2008. Investigation of the rel eva nce of 3’UTR CAG repeats and toxic gain-of-function mechanisms at the RNA level. The 23rd Joint Annual Conference of Biomedical Sciences () page158, P161.

    34. L-C Tu, C-W Lin, Y-T Lin, Y-F Liu, and H Pan. 2008. Functional studies of muscleblind proteins in early zebrafish development. The 23rd Joint Annual Conference of Biomedical Sciences () page156, P155.

    35. L.K. Chen*, H.R. He, and H. Pan. 2007. Investigation of the roles for CAG repeats in RNA-mediated pathogenesis. The 22th Joint Annual Conference of Biomedical Sciences (Taiwan) page185, P332. (*優秀壁報論文獎)

    36. H-Y Cheng and H Pan. 2007. Identification and functional an analysis sis of a novel homeobox gene, Irxl1, in zebrafish embryonic development. Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology () 15: 75.

    37. L-C Tu, H-Y Liu and H Pan. 2007. Differential expression and functions of two muscleblind paralogs in early zebrafish development. Fifteenth Symposium on Recent Advances in Cellular and Molecular Biology (Taiwan) 15: 76. (*優秀壁報論文獎)

    38. Pan H, R-J Hsu, C-Y Li, K-M Hsiao. 2005. Long tract of untranslated CAG repeat is pathogenic in transgenic mice. 55th Annual meeting of The Am eric an Society of Hu ma n Genetics, Salt Lake City, . p405 2234/W.

    39. Pan H, R-J Hsu, C-Y Li. 2005. A transgenic mouse model of untranslated CAG trinucleotide repeat expansion. 4th NHRI Conference on Developmental Biology (). p13. (Invited Speaker)

    40. Pan H. 2005. Long tract of untranslated CAG repeat triggers pathogenic alteration in transgenic mice. Symposium on Developmental Biology in Tunghai University (). p20. (Invited Speaker).

    41. Pan H and Hsu H.-M. 2004.Expression and functional an aly sis of zebrafish p73 during development. The 6th international conference on zebrafish development and genetics. Madison, WI, . p559.

    42. Hsu H.-M. and Pan H. 2004. Developmental expression and functional an aly sis of p73 in zebrafish. Twelfth Symposium on Recent Advances in Cellular and Molecular Biology () 12: 60.

    43. Li C.-Y., Hsu R.-J. and Pan H. 2004. Aberrant muscle differentiation, gene expression and sperm motility in transgenic mice with (CAG)n trinucleotide repeat expansion. Twelfth Symposium on Recent Advances in Cellular and Molecular Biology (Taiwan) 12: 56. (*優秀壁報論文獎)

    44. Hsu R.-J., Lin M.-J., Li C.-Y. and Pan, H. 2003. Altered protein expression and electromyographic pattern in transgenic mice expressing (CAG)n trinucleotide repeat expansion. Eleventh Symposium on Recent Advances in Cellular and Molecular Biology (Taiwan) 11: 104. (*優秀壁報論文獎)

    45. Dung H.-N., Li C.-L. and Pan, H. 2002. Isolation and characterization of zebrafish p73 cDNA. Tenth Symposium on Recent Advances in Cellular and Molecular Biology () 10: 84.

    46. Chiang S.-Y., Li Y.-Y., Lin M.-J., Wu Y.-C., Pan, H. and Hsiao K.-M. 2002. Pathogenic effects of expanded CUG repeat in transgenic C. elegans. Tenth Symposium on Recent Advances in Cellular and Molecular Biology () 10: 43.

    47. Li Y.-Y., Tsai W.-T., Hsiao K.-M., and Pan, H. 2001. A significant higher number of CAG repeats in the Machado-Joseph disease locus of myotonic dystrophy genome. Joint Annual Conference of Biomedical Sciences () 16:415.

    48. Chiang S.-Y., Ku W.-Y., Pan, H., and Hsiao K.-M. 2001. Myotonic dystrophy in . Joint Annual Conference of Biomedical Sciences () 16:412.

    49. Tsai W.-T., Li Y.-Y., Hsiao K.-M., and Pan, H. 2001. Comparison of (CAG/CTG)n frequency distribution at four disease loci in nor ma l and azoospermia populations in . Symposium on Recent Advances in Cellular and Molecular Biology () 9:52.

    50. Ku W.-Y., Lin H.-M., Li T.-C., Li S.-Y., Pan, H., and Hsiao K.-M. 2001. CTG repeat distribution and founder effect of the myotonic dystrophy mutation in . Symposium on Recent Advances in Cellular and Molecular Biology () 9:52.

    51. 潘惠錦 (1989) 碩士論文:吳郭魚腦下腺泌乳激素之研究

    52. Huichin Pan (1995) Ph. D thesis: Regulation of cell proliferation and cell death in the developing mouse lensby tumor suppressors Rb and p53.