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分類清單
李月君
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李月君 教授

Dr. Yueh-Chun Li


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Tel:(04)2473-0022 ext 11814;12314

Fax:(04)2324-8187

ycl@csmu.edu.tw

學經歷
學歷:
  • 國立清華大學生命科學系博士 1996-2001
  • 國立清華大學生命科學研究所碩士 1990-1992
  • 私立高雄醫學大學藥學系 1986-1990
經歷:
  • 私立中山醫學大學生物醫學科學系 教授 2006-present
  • 私立中山醫學大學生物醫學科學系 副教授 2002-2006
  • 私立中山醫學院生命科學系 講師 1997-2002
  • 私立中山醫學院生物科 講師 1992-1997

研究方向及計畫
  • 91年度:
    哺乳類動物著絲點DNA的分子結構及功能之研究(1/3)
  • 92年度:
    哺乳類動物著絲點DNA的分子結構及功能之研究(2/3) (NSC 92-2320-B-040-048)
  • 93年度:
    哺乳類動物著絲點 DNA 的分子結構及功能之研究(3/3) (NSC 93-2320-B-040-055)
  • 94年度:
    衛星DNA的功能研究及人造染色体的建構 (NSC 94-2320-B-040-042)
  • 95年度:
    衛星DNA之著絲點功能及核型演化的研究 (NSC 95-2311-B-040-001)
  • 96年度:
    著絲點DNA之基因組構造,演化及功能的研究 (NSC 96-2311-B-040-004)
  • 97年度:
    著絲點蛋白質H連結的著絲點DNA之特性分析 (NSC 96-2311-B-040-003)
  • 98年度:
    著絲點蛋白質H連結的著絲點DNA之特性分析 (NSC 97-2311-B-040-003)

專長及教授課程
  • 分子生物學
  • 普通生物學
  • 分子細胞遺傳學
研究著作
  1. 期刊論文
    1. Chien, S.-C., Li, Y.C., Li, L.-H., Wu, J.-Y., Hsu, P.-C., Shi, S.-L., Tsai, F.J., Lin, C.C. A new familial insertion, ins(18;9)(q12.2;q33.1q31.1) with a 9q31.1-9q33.1 deletion in a proband with a cleft lip and palate. Am J Med Genet 2010 SCI (In Press)

    2. Pi -Lin Sung., Sheng-Ping Chang., Kuo-Chang Wen.,Chia-Ming Chang., Ming-Jie Yang., Lin-Chao Chen., Kuan-Chong Chao., Chi-Ying F. Huang., Yueh-Chun Li*., Chyi-Chyang Lin*.Small Supernumerary Marker Chromosome Originating From Chromosome 10 Associated With an Apparently Normal Phenotype. American Journal of Medical Genetics Part A 2009.149A:2768

    3. Shu-Chin Chien., Y.-C LI., Ming- Ho., Ru-Hsiou Teng., Wei-De Lin., Fuu-Jen Tsai*., Chyi-Chyang Lin*. Rare Rearrangements: A Jumping Satellite in One Family and Autosomal Location of the SRY Gene in an XX Male. American Journal of Medical Genetics Part A 2009.149A: 2775-2781

    4. Ya-Ming Cheng., Tzai-Shiuan Li., Lie-Jiau Hsie., Yueh-Chun Li*., Chyi-Chyang Lin*. Complex genomic organization of Indian muntjac. Chromosome Research 2009(17):1051-1062

    5. Lin,C.C., Hsu, P.C., Li, T.S., Liao, S.J., Cheng, Y.M., Hsieh, L.J., Li, Y.C*. Construction of an Indian muntjac BAC library and production of the most highly density FISH ma p of the species. Zoological Studies 2008; 47:282-292 SCI

    6. Lin, C.C., Li, Y.-C., Liu, P.-P., Hsieh, L.-J., Cheng, Y.-M., Teng, R.-H., Shi, S.-L., Tsai, F.-J. Identification and characterization of a new type of asymmetrical dicentric chromosome derived from a single ma ternal chromosome 18. Cytogenet Genome Res 2007; 119:291-296 SCI

    7. Chen, C.P., Su, Y.N., Lin, C.C., Li, Y.C., Hsieh, L.J., Lee, C.C., Wang, W. Genetic counseling of prenatally detected unbalanced t(Y;15)(q12;p13). Genet Couns. 2007; 18:455-457. SCI

    8. Chang, C.M., Yang, M.J., Lin, C.C., Li, Y.C., Sung, P.L., Lee, P.C., Chen, L.C., Hsieh, L.J., Hwang, K.S., Chen, C.P., Chao, K.C. Partial trisomy 3p and monosomy 7p associated with tetralogy of Fallot and infantile seizure. Taiwanese Journal of Obstetrics & Gynecology 2007; 46:288-292

    9. Li, Y.C., Tzeng, C.C., Song, J.H., Tsia, F.J., Hsieh, L.J., Liao, S.J., Tsai, C.H., Van Meir, E.G., Hao, C., Lin, C.C. Genomic alterations in hu ma n ma lignant glio ma cells associate with the cell resistance to the combination treatment with tumor necrosis factor-related apoptosis-inducing ligand and chemotherapy. Clin Cancer Res. 2006; 12:2716-2729.

    10. Lin, C.C. and Li, Y.C.* Chromoso ma l distribution and organization of three cervid satellite DNAs in Chinese water deer (Hydropotes inermis). Cytogenet Genome Res 2006; 114:147-154. SCI

    11. Chen, C.P., Lin, C.C., Li, Y.C., Hsieh, L.J., Lee, C.C., Wang, W. Pri ma ry ovarian failure in a mentally retarded wo ma n with a de novo unbalanced X;autosome translocation. Fertil. Steril 2006; 86:1514. e1-2 SCI

    12. Chen, C.-P., Lin, S.-P., Lin, C. C., Chen, Y.-J., Chern, S.-R., Li, Y.C., Hsieh, L.-J., Lee, C.-C., Pan, C.-W., Wang, W. Molecular cytogenetic an aly sis of de novo dup(5)(q35.2q35.3) and review of the literature of pure partial trisomy-5q. Am J Med Genet 2006:140A:1594-1600. SCI

    13. Lin C.C., Hsieh, Y.Y., Wang, C.H., Li, Y.C., Hsieh, L.J., Lee, C.C., Tsai, C.H., Tsai, F.J. Prenatal detection and characterization of a s ma ll supernumerary ma rker chromosome (sSMC) derived from chromosome 22 with apparently nor ma l phenotype. Prenat Diagn 2006; 26:898-902 SCI

    14. Chen, C.-P., Lin, S.-P., Lin, C. C., Li, Y.C., Hsieh, L.-J., Huang, J.-K., Lee, C.-C., Wang, W. Spectral karyoty ping and fluorescence in situ hybridization an aly sis of de novo partial trisomy 7p (7p21.2-->pter) and partial monosomy 12q (12q24.33-->qter). Genetic Counseling 2006; 17:57-63. SCI

    15. Chen, C.-P., Lin, C. C., Chang T.-Y., Li, Y.C., Hsieh, L.-J., Lee, C.-C., Chen L.-F., Wang, W. Prenatal diagnosis of a micropenis in a ma le fetus with partial trisomy 12q (12q24.32àqter) and partial monosomy 21q (21q22.2àqter). Prenat Diagn 2006 ; 26:757-759 SCI

    16. Chen, C.P., Lin, S.P., Lin, C.C., Li, Y.C., Hsieh, L.J., Chern, S.R., Lee, C.C., Chen, L.F., Hua, H.M., Wang, W. Prenatal diagnosis of low-level mosaicism for a s ma ll XIST-negative supernumerary ring X chromosome in a nondysmorphic ma le fetus. Prenat Diagn. 2006; 26:387-391. SCI

    17. Chen, C.P., Chern, S.R., Lin, C.C., Wang, T.H., Li, Y.C., Hsieh, L.J., Lee, C.C., Hua, H.M., Wang, W. Prenatal findings and molecular cytogenetic an aly ses of partial trisomy 12q (12q24.32-->qter) and partial monosomy 21q (21q22.2-->qter). Prenat Diagn. 2006; 26:313-20. SCI

    18. Chen, C.P., Chern, S.R., Lee, C.C., Lin, C.C., Li, Y.C., Hsieh, L.J., Chen, W.L., Wang. W. Prenatal diagnosis of de novo t(2;18;14)(q33.1;q12.2;q31.2), dup(5)(q34q34), del(7)(p21.1p21.1), and del(10)(q25.3q25.3) and a review of the prenatally ascertained de novo apparently balanced complex and multiple chromoso ma l rearrangements. Prenat Diagn. 2006;26:138-146. SCI

    19. Chen, C.P., Lin, S.P., Chern, S.R., Lin, C.C., Li, Y.C., Lee, C.C., Hsieh, L.J., Chen, W.L., Wang, W. Molecular cytogenetic an aly sis of de novo dup(5)(q33.1q31.1) associated with abnor ma l perinatal findings. Prenat Diagn. 2006;26:181-183. SCI

    20. Li, Y.C., Cheng, Y.M., Hsieh, L.J., Ryder, O. A., Yang, F., Liao, S.J., Hsiao, K.M., Tsai, F.J., Tsai, C.H., Lin, C. C. Karyotypic evolution of a novel cervid satellite DNA family isolated by microdissection from the Indian muntjac Y-chromosome Chromoso ma 2005; 114:28-38 SCI

    21. Chen, C.P., Lin, S.P., Lin, C.C., Li, Y.C., Hiesh, L.J., Chern, S.R., Lee, C.C., Chen, Y.J. and Wang, W. Spectral karyoty ping , fluorescence in situ hybridization and molecular genetic an aly sis of de novo partial trisomy 7p (7p15.1 --> pter) and partial monosomy 9p (9p22 --> pter). Prenatal Diag 2005; 25:1170-1172. SCI

    22. Shyu, Y.C., Lee, T.L.,Ting, C.Y., Wen, S.C., Hwieh, L.J., Li, Y.C., Hwang, J.L., Lin, C.C., Shen, C.K. Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the ma m ma lian beta-like globin gene locus. Molecular and Cellular Biology 2005;. 25:10365-10378. SCI
    23. Chen, C.P., Chern, S.R., Lin, S.P., Lin, C.C., Li, Y.C., Wang, T.H., Lee, C.C., Pan, C.W., Hsieh, L.J., Wang, W. A paternally derived inverted duplication of distal 14q with a terminal 14q deletion. Am J Med Genet A 2005;.139:146-150. SCI
    24. Chen, C.P., Lin, S.P., Lin, C.C., Li, Y.C., Hiesh, L.J., Lee, C.C., Chen, Y.J. and Wang, W. Spectral karyoty ping and fluorescence in situ hybridization an aly sis of de novo partial duplication of Yq (Yq11.2-->qter) and partial monosomy 5p (5p15.3-->pter). Prenatal Diag 2005;. 25:723-725. SCI

    25. Chen, C.P., Lin, S.P., Lin, C.C., Li, Y.C., Chern, S.R., Chen, W.M., Lee, C.C., Hiesh, L.J., and Wang, W. Perinatal findings and molecular cytogenetic an aly sis of de novo partial trisomy 16q (16q22.1-->qter) and partial monosomy 20q (20q13.3-->qter). Prenatal Diag 2005;. 25:112-118. Review. SCI

    26. Chen, C.P., Lin. C.C., Li, Y.C., Chern, S.R., Lee, C.C., Chen, W.L., Lee, M.S., Wang, W. and Tzen, C.Y. Clinical, cytogenetic, and molecular an aly ses of prenatally diagnosed mosaic tetrasomy for distal chromosome 15q and review of the literature. Prenatal Diag 2004;. 24:767-773. Review SCI

    27. Chiang, P.Y., Lin, C.C., Liao, S.J., Hsieh, L.J., Li, S.Y., Chao, M.C., Li, Y.C.* Genetic an aly sis for two subspecies of the Reeve’s ma ntjac (Cervidae: Muntiacus reevesi) by karyoty ping and Satellite DNAs an aly ses. Zoological Studies 2004; 43: 749-758 SCI

    28. Lin, C.C., Chiang, P.Y., Hsieh, L.J., Liao S.J., Chao, M. C., Li, Y.C.* Cloning, characterization and physical ma p ping of three cervic satellite DNA families in the genome of the Formosan muntjac (Muntiacus reevesi micrurus) Cytogenet Genome Res 2004; 105:100-106. SCI

    29. Li, Y.C., Lee, C., Chang W.S., Li, S. Y. and Lin, C.C. Isolation and identification of a highly conserved centrom eric repetitive DNA element in several Cervidae species. Chromoso ma 2002; 111:176-183. SCI
  2. 研討會
    • Shi,S.L., Tsai,C.H., Tsai,F.J. Identification and characterization of a new type of asymmetrical dicentriv chromosome derived from asingle maternal chromosome 18. 57th Annual Meeting of the American Soceity of Human Genetics. San Diego, CA, Oct, 2007

    • Y. C., Chen, C.P> Hsieh L.J., Tsai F. J., Lin C.C. Identification of marker chromosomes using FISH-based technology and DNA polymorphic marker. 57th Annual Meeting of the American Soceity of Human Genetics. San Diego, CA, Oct, 2007

    • Li, Y. C., Hsu, P.C., Li,T.S., Cheng, Y.M., Hsieh, L.J., Liao, S.J., Lin, C.C. High density BAC clone mapping and defining the karyotype evolution of Formosan deer. 56th Annual American Socity of Human Genetics Meeting. New Orleans, LA, Oct, 2007

    • Li, Y.C., Lien, I.C., Chou, I.C., Hsieh, L.J., Tsai, F.J., Lin, C.C. An unbalanced subtelom eric translocation occurred at 16q and 19p in a family with mental retardation was detected by using MLPA, FISH and STS ma rker polymorphism assay. 2006 Annual Clinical Genetics Meeting of the Am eric an College of Medical Genetics. San Diego, California , March, 2006.

    • Li Y.C., Lin C.C., Chao M.F., Liao S.J., Hsieh L.J., Shiu M.M. Evaluating individuals with mental retardation using subtelom eric FISH and MLPA an aly ses. 55h annual Am eric an Society of Hu ma n Gentics Meeting. Salt Lake City, Utah , October, 2005 (Am eric an Journal of Hu ma n Genetics:A859)

    • Li, Y. C., Hsieh L.J., Pan Y.J., Tsai F. J., Lin C.C. Defining the breakpoints of an unbalanced translocation involving 9p and 18q by prenatal molecular cytogenetics an aly sis. 2005 Annual Clinical Genetics Meeting of the Am eric an College of Medical Genetics. Dallas, Texas , Marc

    • Li, Y.C., Cheng, Y.M., Hsieh, L.J., Liao, S.J., Lin, C.C. A novel satellite DNA family generated by microdissection of Y-chromosome of Indian muntjac (M. muntjac vaginalis). 54th annual Am eric an Society of Hu ma n Gentics Meeting. Toronto, , October, 2004 (Am eric an Journal of Hu ma n Genetics :A1030)

    • Lin, C.C., Li, Y.C., Hsieh, L.J., Chen, C.P. , Ko, T.M., Tzeng, C.C., Yang, M.L., Fang, J.S., Li, M.S., Tzeng, L.S., Pan, Y.J., Lin, S.K., Tsai, F.J. A Referral Center for Prenatal FISH Study in —First Year Experience. 54th annual Am eric an Society of Hu ma n Gentics Meeting. Toronto, , October, 2004 (Am eric an Journal of Hu ma n Genetics 77:A991)

    • Li, Y.C., Liao, S.J., Hsieh, L.J., Lin, C.C. Reconstruction of 3D-spatial structure of ma m ma lian centromere. 53rd annual Am eric an Society of Hu ma n Gentics Meeting. Los Angel, , November, 2003 (Am eric an Journal of Hu ma n Genetics 73:A 838)

    • Lin, C.C., Hsieh, L.J., Pan, Y.J., Li, Y.C. Prenatal cytogenetic detection of an unbalanced karyotype involving 9p- and 18q duplication in a fetus with apparently normal phenotype. Los Angel, , November, 2003 (Am eric an Journal of Human Genetics 73:A762)

    • Li, Y.C., Lee, C., Chang, W.S., Li, S. Y. and Lin, C.C. Isolation and identification of a novel centrom eric satellite DNA family highly conserved in several mammalian species. 52nd annual Am eric an Society of Human Gentics Meeting. Baltimore, , October, 2002 (Am eric an Journal of Human Genetics 71:A763)

    • Lin, C.C., Li, Y.C., Lee, C. How telocentric mouse chromosomes are? 52nd annual Am eric an Society of Human Gentics Meeting. Baltimore, , October, 2002 (Am eric an Journal of Human Genetics 71:A762) Li, Y.C., Lee, C., Hseu, T.H., Li, S. Y. and Lin, C.C. High resolution map ping of centrom eric satellite DNA families. 51th annual Am eric an Society of Human Genetics Meeting. San Diego, , October, 2001 (Am eric an Journal of Human Genetics 69:A329)
  3. 專書
    • 林齊強 李月 君 (2003) 分子檢驗專書第二部第八章”分子細胞遺傳技術概觀”