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分類清單
楊琇雯
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楊琇雯 教授

Dr. Hsiu-Wen Yang


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Tel:(04)2473-0022 ext 11813;12316

Fax:(04)2324-8187

hwy@csmu.edu.tw

學經歷
學歷:
  • 1997 博士 英國里茲大學 生理學系
  • 1991 碩士 國立陽明大學 生理學研究所
  • 1989 學士 輔仁大學 食品營養學系
經歷:
  • 2012 - present 教授 中山醫學大學 生物醫學科學學系
  • 2004 - 2012 副教授 中山醫學大學 生物醫學科學學系
  • 1999 - 2004 助理教授 中山醫學大學 生命科學系
  • 1997 - 1999 博士後研究員 英國倫敦大學 神經學研究所 神經生理學系
    (Sobell Department of Neurophysiology, Institute of Neurology, University College London, UK)
  • 1991 ~ 1993 電顯技術員 長庚大學 電子顯微鏡中心

研究方向及計畫
  • 98年度:大白鼠染色體14A3區性腺表現基因群的分子特性與功能分析(1/3) (97-2320-B-040-010-MY3)
  • 97年度:大白鼠中腦A7核區正腎上腺素神經元A型鉀離子電流之分子和生理特性分析與角色探討(3/3)
    (95-2320-B-040-011-MY3)
  • 96年度:大白鼠中腦A7核區正腎上腺素神經元A型鉀離子電流之分子和生理特性分析與角色探討(2/3)
    (95-2320-B-040-011-MY3)
  • 95年度:大白鼠中腦A7核區正腎上腺素神經元A型鉀離子電流之分子和生理特性分析與角色探討(1/3)
    (95-2320-B-040-011-MY3)
  • 94年度: 大白鼠A7/A5區域正腎上腺素神經元與三叉神經運動系統關係之研究(2/2)
    (NSC 94-2320-B-040-008-)
  • 93年度:大白鼠A7/A5區域腎上腺素神經元與三叉神經運動系統關係之研究(1/2)
    (NSC 93-2320-B040-040)
  • 92年度:大白鼠三叉神經運動系統之局部神經迴路結構研究(3/3) (92-2320-B-040-019-)
  • 91年度: 大白鼠三叉神經運動系統之局部神經迴路結構研究(2/3) (91-2320-B-040-021-)
  • 90年度: 大白鼠三叉神經運動系統之局部神經迴路結構研究(1/3)(90-2314-B-040-011-)
  • 89年度:GABA與GLYCINE共同存在之生理意義:發育中及去除GABA或GLYCINE之大白鼠三叉神經運動系統之研究(2/2)
  • 88年度:GABA與GLYCINE共同存在之生理意義:發育中及去除GABA或GLYCINE之大白鼠三叉神經運動系統之研究(1/2)

專長及教授課程
  • 專長
    • 神經科學
    • 基礎醫學
    • 電子顯微鏡
  • 教授課程
    • 神經生物學
    • 普通生物學
研究著作
  1. 期刊論文
    1. Min, M.Y., Wu, Y.W., Shih, P.Y., Lu, H.W., Wu, Y., Hsu, C.L., Li, M.J., and Yang, H.W.* (2010). Roles of A-type potassium currents in tuning spike frequency and integrating synaptic transmission in noradrenergic neurons of the A7 catecholamine cell group in rats. Neuroscience (in press).

    2. Min, M.-Y., Shih, P.-Y., Lu, H.-W., Lee, M.-L., and Yang, H.-W. (2009). Neurokinin 1 receptor activates transient receptor potential-like currents in noradrenergic A7 neurons in rats. Mol. Cel. Neurosci. 42, 56-65.

    3. Min, M.-Y., Wu, Y.-W., Shih, P.-Y., Lu, H.-W., Lin, C.-C., Wu, Y., Li, M.-J., and Yang, H.-W. (2008).Physiologicl and morphological properties of, and effect of substance P on, neurons in the A7 catecholamine cell group in rats. Neurosci. 153, 1020-1033.

    4. Lin, Y.-W., Yang, H.-W., Chiu, T.-H., and Min, M.-Y. (2008). Inhibition of associate long-termdepression by activation of b-adregergic receptors in rat hippocampal CA1 synapses. J. Biomed. Sci. 15(1), 123-131.

    5. Yang, S.-C., Chiu, T.-H., Yang, H.-W*., and Min, M.-Y. (2007). Presynaptic adenosine A1 receptors modulate excitatory synaptic transmission in the posterior piriform cortex in rats. Brain Res. 1156, 67-79.

    6. Min, M.-Y., Hsu, P.-C., Lu, H.-W., Lin, C.-J., and Yang, H.-W*.(2007) Postnatal development of noradrenergic terminals in the rat trigeminal motor nucleus: a light and electron microscopic immunocytochemical an aly sis. Anat. Rec. 290, 96-107.

    7. Lin, Y.-W#., Yang, H.-W#., Wang, H.-J., Gong, C.-L., Chiu, T.-H., and Min, M.-Y. (2006). Spike-timing-dependent plasticity (STDP) at resting and conditioned lateral perforant path synapses on granule cells in the dentate gyrus: different roles of NMDA and group I metabotropic gluta ma te receptors. Eur. J. Neurosci. 23, 2362-2374 (# These authors contributed equally).

    8. Lin, Y.-W., Yang, H.-W., Min, M.Y., and Chiu, T.-H. (2004). Heat-shock pretreatment prevents suppression of long-term potentiation induced by scopolamine in rat hippocampal CA1 synapses. Brain Res. 999, 222-226.

    9. Min, M.-Y., Hsu, P.-C., and Yang, H.W*. (2003). The physiological and morphological characteristics of interneurones caudal to the trigeminal motor nucleus in rats. Eur. J. Neurosci. 18, 2981-2998.

    10. Lin, Y.-W., Min, M.-Y., Chiu, T.-H., and Yang, H.W*. (2003). Enhancement of associative long-term potentiation by activation of b-adrenergic receptors at CA1 synapses in rat hippocampal slices. J. Neurosci. 23(10), 4173-4181.

    11. Yang, H.-W. and Lemon, R.N. (2003). An electron microscopic examination of the corticospinal projection to the cervical spinal cord in the rat: lack of evidence for cortico-motoneuronal synapses. Exp. Brain Res. 149(4), 458-469.

    12. Yang, H.-W., Lin, Y.-W., Yen, C.-D., and Min, M.-Y. (2002). Change in bi-directional plasticity at CA1 synapses in hippocampal slices taken from 6-hydroxydopamine treated rats: the role of endogenous norepinephrine. Eur. J. Neurosci. 16(6), 1117-1128.

    13. Min, M.Y., Appenteng, K. and Yang, H.-W. (2002). Role of GABAB receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons. J. Biomed. Sci. 9(4), 348-358.

    14. Liang, P.I., Yang, H.-W., Lin, Y.-W., Yen, C.D., and Min, M.Y. (2002). The effect of prior prolonged low frequency stimulation on the further synaptic plasticity at hippocampal CA1 synapses. Chinese J. Physiol. 45(2), 63-68.

    15. Maier, M.A., Ar ma nd, J., Kirkwood , P.A., Yang, H.-W., Davis , J.N., and Lemon, R.N. (2002). Differences in the corticospinal projection from pri ma ry motor cortex and supplementary motor area to ma caque upper limb motoneurons: an anatomical and electrophysiological study. Cereb. Cortex 12(3), 281-296.

    16. Lemon, R.N., Maier, M.A., Ar ma nd, J., Kirkwood , P.A., Yang, H.-W. (2002). Functional differences in corticospinal projections from ma caque pri ma ry motor cortex and supplementary motor area. Adv. Exp. Med. Biol. 508, 425-434.

    17. Henderson , Z., Morris, N.P., Grimwood, P.D., Fiddler, G., Yang, H.-W., and Appenteng, K. (2001). Morphology of local axon collaterals of electrophysiological characterized neurons in the rat medial septal/diagonal band complex. J. Comp. Neurol. 430(3), 410-432.
  2. 研討會論文
    • Wu, Y., Lin, C.-C., Min, M.-Y., and Yang, H.-W. (2008). GABAB receptor mediated tonic inhibition in noradrenergic neurons in A7 catecholamine cell group. Soc. Neurosci. Abstr Viewer/Itinerary Planner. Program No. 72.13.

    • Lee, M-L., Yang, H.-W., and Min, M.-Y. (2008). Identification of synaptic connection between pontine parabrachial area and A7 catecholaine cell group in rats. Soc. Neurosci. Abstr Viewer/Itinerary Planner. Program No. 72.10.

    • Hsu, C.-L., Cheng, S.-J., Yang, H.-W., Min, M.-Y. (2008). Synaptic transmission and plasticity of cortical and sensory inputs on relay neurons in the ventrovasal nucleus of rat thalamus. Soc. Neurosci. Abstr Viewer/Itinerary Planner. Program No. 39.1.

    • Cheng, S.-J., Li, M.-J., Yang, H.-W., Min, M.-Y. (2008). Activation of extracellular signal-regulated kinase induces a long-term potentiation of synaptic transmission in parabrachio-amygdaloid pain pathway. Soc. Neurosci. Abstr Viewer/Itinerary Planner. Program No. 368.3.

    • Lu, H.-W., Min, M.-Y., and Yang, H.-W. (2007). Effect of orexin-A on inhibitory postsynaptic current and membrane excitability in noradrenergic neurons in A7 catecholamine cell group. Soc. Neurosci. Abstr Viewer/Itinerary Planner. Program No. 462.19.

    • Hsu, C.-L., Cheng, S.-L., Yang, H.-W., Min, M.-Y. (2007). Synaptic plasticity of sensory input on the relay neurons in ventrobasal nucleus of thalamus. Soc. Neurosci. Abstr Viewer/Itinerary Planner. Program No. 47.11.

    • Wu, Y.-W., Shih, P.-Y., Min, M.-Y., and Yang, H.-W. (2006). Role for A-type postassium current in spiking properties of neurons in A7 catecholamine cell group. The Twenty first Joint Annual Conference of Biomedical Science 21, O072

    • Shih, P.-Y., Wu, Y.-W., Min, M.-Y., and Yang, H.-W. (2006). Charateristics of A-type potassium current evoked in noradrenergic neurons in A7 catecholamine cell group. The Twenty first Joint Annual Conference of Biomedical Science 21, O073

    • Yung, S.-C., Yang, H.-W., Chiu, T.-H., and Min, M.-Y. (2006). Role of adenosine in synaptic transmission in rat piriform cortex. The Twenty first Joint Annual Conference of Biomedical Science 21, O074.

    • Min, M.-Y., Hsu, P.-C., and Yang, H.-W. (2004). Whole cell recording from neurons located in pontine A7 nucleus in rat brainstem slices. Soc. Neurosci. Abstr. Viewer/Itinerary Planner. Program No. 521.10.

    • Yang, H.-W. and Min, M.-Y. (2004). The excitatory and inhibitory synaptic activity recorded from adrenergic neurons of A7 area in rats. Soc. Neurosci. Abstr. Viewer/Itinerary Planner. Program No. 521.9.

    • Jeng, S.-Y., Yang, H.-W., and Min, M.-Y. (2004). Transition of early-LTP into late-LTP by so ma tic q-burst stimulation at CA1 synapses. The Nineteenth Joint Annual Conference of Biomedical Science 19, P412.

    • Hsu, P.-C., Min, M.-Y., and Yang, H.-W. (2004). Postnantal development of noradrenergic fibers in the rat trigeminal motor nucleus. The Nineteenth Joint Annual Conference of Biomedical Science 19, P406.

    • Lin, Y.-W. Yang, H.-W., Yen, C.-D., Wang, H.-J., Yang, C..-S., Chiu-T.-H., and Min, M.Y. (2002). Timing based heterosynaptic plasticity at CA1 synapses in hippocampal slices. Soc. Neurosci. Abstr. 32, 152.10.

    • Yen, C.-D., Yang, H.-W., Lin, Y.-W., Yang, C..-S., Wang, H.-J., Chiu-T.-H., and Min, M.Y. (2002). Activation of b-adrenergic receptors enhances heterosynaptic plasticity at hippocampal CA1 synapses. Soc. Neurosci. Abstr. 32, 443.7.

    • Yang, H.-W., Hsu, P.-C., and Min, M.-Y. (2002). The physiological and morphological characteristics of trigeminal premotor interneurons. Soc. Neurosci. Abstr. 32, 856.4.

    • Yang, H.-W., Lin, Y.-W., Yen, C.-D., and Min, M.-Y. (2002). Activation of b-adrenergic receptors enhances timing-based long-term potentiation (LTP) at CA1 synapses. J. Physiol.( London ) 543P, 30P.

    • Yang, H.-W., Chen, S.-H., and Min, M.-Y. (2001). The elcectrical and morphological properties of interneurons lying dorsal caudal to the rat trigeminal motor nucleus. Soc. Neurosci. Abstr. 31, 295.4.

    • Lin, Y.-W., Yang, H.-W., and Min, M.-Y. (2001). Depletion of norepinephrine (NE) fibers alters synaptic plasticity at the rat CA1 synapses. Soc. Neurosci. Abstr. 31, 920.6.

    • Min, M.-Y., and Yang, H.-W. (2001). The properties of interneurons lying dorsal-caudal to rat trigeminal motor nucleus. The Sixth Joint Annual Conference of Biomedical Sciences 6, O45.

    • Yang, H.-W., Tyan, J.-Y., Lin, I.-W., and Min, M.-Y. (2001). Development of GABAergic and glycinergic nerve terminals on rat trigeminal motoneurons. The Sixth Joint Annual Conference of Biomedical Sciences 6, P230.

    • Lin, I.-W., Yang, H.-W., and Min, M.-Y. (2001). Depletion in norepinephrine (NE) fibers alters synaptic plasticity in the rat CA1 synapses. The Sixth Joint Annual Conference of Biomedical Sciences 6, P231.

    • Min, M.-Y., and Yang, H.-W. (2001). g-Aminobutyric acid (GABA) and glycine mediating inhibitory postsynaptic activity in rat trigeminal motoneurons in-vitro. The Sixth Joint Annual Conference of Biomedical Sciences 6, P236.
  3. 專書及專書研討會論文
    • Min, M.-Y., Appenteng, K., Batten, T.F.C., and Yang, H.W. (1999). Inhibitory control of excitatory transmission. In “Neurobiology of Mastication-From Molecular to System Approach” (Y. Nakamura, Ed), pp61-77. Elsevier Press.
    • Lemon, R.N., Baker, S.N., Davis , J.A., Kirkwood , P.A., Maier, M.A., and Yang, H.-W. (1998). Cotrical mechanisms in reaching and gras ping . In “Sensory Guidance of Movement, Novartis Foudation Symposium 218” (G.R. Bock and J.A. Goode, Eds), pp202-218. John Wiley & Sons, Chichester .