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  4. 林明忠

林明忠

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林明忠 教授

　

　

(Dr. Min-Jon Lin)

　

　

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Tel:(04)2473-0022

ext 11486;12315

Fax:(04)2324-8187

                                                                                             

　

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學歷:

臺灣大學醫學院藥理學博士

臺灣大學藥理學研究所博士後研究

國家衛生院獎助既臺灣大學臺大醫院耳鼻喉部博士後研究

經歷:

中山醫學大學副教授 2007,06-迄今

中山醫學大學助理教授 2005,08-2007,05

　

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98年度：   

以異源性表達方式探討人類KCNQ4管道蛋白受磷酸化作用其序列位點(C-端與S4-S5段)與功能變化之研究.(2/3) (國科會: 97-2320-B-040-002-MY3).

97年度：   

以異源性表達方式探討人類KCNQ4管道蛋白受磷酸化作用其序列位點(C-端與S4-S5段)與功能變化之研究.(1/3) (國科會: 97-2320-B-040-002-MY3). 

 

96年度：

以異源性表達方式探討補骨脂成份衍生物與KCNQ阻斷藥物對於KCNQ4基因與多型性功能的作用之研究 (國科會：96-2320-B-040-013-)　

95年度：

中藥補骨脂改善聽覺功能分子機制之研究 (國科會：95-2320-B-040-007)　

94-95年度：

藥酒癮併發聽覺神經系統障礙臨床與基礎之研究(衛生署：DOH95-TD-M-113-035)

93年度：

台灣聽障患者中KCNQ4基因(鉀電流)變異表現在爪蟾卵母細胞之功能分析 (國科會: NSC 93-2314-B-040-005)　

92年度：

一氧化氮/cGMP 對於聽神經- 外毛細胞運動性調控之研究 (國科會: NSC 92-2314-B-040-026)　

91年度：

蛋白-G與磷酸化對耳蝸毛細胞鈣離子電流及其運動性調控作用之研究 (國科會: NSC 89-2320-B-040-071)　

89年度：

蛋白質激★鵀桵膜繰茩M及神經節鈣離子管道的調控作用 (國科會: NSC 89-2320-B-040-071)

　

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  • 神經生物學

  • 藥理學

  • 普通生物學　　

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  (A):期刊論文 (SCI)  

  • Kuang-Ming Hsiao, Ren-Yu Huang, Pei-Hua Tang, Min-Jon Lin*. Functional study of CLC-1 mutants expressed in Xenopus oocytes reveals that a C-terminal region Thr891-Ser892-Thr893 is responsible for the effects of protein kinase C activator. Cellular Physiology and Biochemistry, 2010 25:687-694. (SCI, corresponding author)
  • Tzu-rong SU, Cay-huyen CHEN, Shih-jen HUANG, Chun-yi LEE, Mao-chang SU, Gwan-hong CHEN, Shuan-yow LI, Jiannjou YANG, Min-jon LIN (2009) Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes. Acta Pha ma cologica sinica. 30: 1220-1226. (通信作者, IF = 3 x 4 x 5 =60)
  • Min-Jon Lin, Ren-Yu Huang; Huichin Pan and Kuang-Ming Hsiao (2008) Functional studies of the effect of NO donor on hu ma n CLCN1 polymorphism/mutants expressed in Xenopus laevis oocytes. Biochemical and Biophysical Research Communications. 365: 724-728. (第一作者, IF = 3x 4x 5 =60).
  • Hsiu-Yueh Lee, Pei-Hu Liao, Min-Jon Lin, Ruey-Hseng Lin (2006) A study of drug interactions in prescriptions for patients with heart failure. Chung Shan Medical Journal 17: 71-84. (第三作者)
  • Min-Jon Lin, Tsai-Hong Yu, Huichin Pan and Kuang-Ming Hsiao (2006) Functional characterization of CLCN1 mutations in Taiwanese patients with myotonia congenita via heterologous expression. Biochemical and Biophysical Research Communications. 351: 1043-1047. (第一作者, IF = 3x 4x 5 =60).
  • Ching-Chyuan Su, Shuan-Yow Li, Jiann-Jou Yang, Mao-Chang Su and Min-Jon Lin* (2006) Studies of the effect of ionomycin on the KCNQ4 channel expressed in Xenopus oocytes. Biochemical and Biophysical Research Communications. 348: 295-300. (通信作者, IF = 3 x 4 x 5 =60).
  • Kuan-Yu Chen, Huichin Pan, Min-Jon Lin, Yet-Young Li, Li-Chun Wang, Yi-Chun Wu and Kuang-Ming Hsiao (2007) Length-dependent toxicity of untranslated CUG repeats on Caenorhabditis elegans Biochemical and Biophysical Research Communications 352: 774-779. (第三作者, IF = 3 x 4x 1 =12).
  • Shen-Kou Tsai, Min-Jon Lin , Pei-Hu Liao , Chi-Yea Yang, Su-Man Lin , Sheng-Ming Liu ,Ruey-Hseng Lin, Chun-Lien Chih and Shiang-Suo Huang (2006) Caffeic acid phenethyl ester ameliorates cerebral infarction in rats subjected to focal cerebral ischemia. Life Science, 78: 2758-2762. (第二作者, IF = 3 x 4x 3 =36).
  • Mao-Chang Su, Shiann-Yann Lee, Ching-Ting Tan, Ching-Chyuan Su, Shuan-Yow Li, Ruey-Hseng Lin, Chui-Chen Hung and Min-Jon Lin* (2005) Taicatoxin inhibits the calcium-dependent slow motility of ma m ma lian outer hair cells. Hearing Research, 203: 172-179. (通信作者, IF = 3 x 4 x 5 =60).
  • Henrich Cheng, Shiang-Suo Huang, Su-Man Lin, Min-Jon Lin, Ya-Chun Chu, Chun-Lien Chih, May-Jywan Tsai, and Shen-Kou Tsai (2005) The neuroprotective effect of glial cell line-derived neurotrophic factor in fibrin glue against chronic focal cerebral ischemia in conscious rats. Brain Research, 1033: 28-33. (第四作者, IF = 3 x 4 x 0.5 =6).
  • Chien-Ning Huang , Kai-Li Liu , Chun-Hsu Cheng , Yu-Sheng Lin, Min-Jon Lin and Ting-Hui Lin (2005) PGE2 enhances cytokine-elicited nitric oxide production in mouse cortical collecting duct cells. Nitric Oxide. 12 :150-158. (第五作者, IF = 3 x 4x 0.5 =6).

(以上為五年內)

其它五年外SCI期刊論文參考 (before 2004)

 

  

  •   Lin Min-Jon, Su MC, Tan, CT, Su CC, Li SY, Lin RH, Lin-Shiau SY, Hung, CC and Lee SY (2003) The effect of L-arginine on the slow moyility of ma m ma lian outer hair cell. Hearing Research 178, 52-58.
  •  Lin MJ and Lin-Shiau SY (2000) Suramin protects the murine motor nerves from the toxic effects of presynaptic Ca2+ channel inhibitors. Neuroscience Letters 287: 97-100.
  •  Lin-Shiau SY and Lin MJ (2000) Suramin inhibits the toxic effects of presynaptic neurotoxins at the mouse motor nerve terminals. European Journal of Phar ma cology 382: 75-80. 
  •  Lin MJ and Lin-Shiau SY (1999) Enhanced spontaneous transmitter release at murine motor nerve terminals with cyclosporine. Neurophar ma cology 38: 195-198.
  •  Lin MJ and Lin-Shiau SY (1998) Phorbol ester-induced contractions of mouse detrusor muscle are inhibited by nifedipine. Naunyn-Schmiedeberg's Arch Phar ma col 357: 553-557.
  • Lin-Shiau SY and Lin MJ (1998) Studies on curare-like action of the tripeptide carbobenzoxy-Gly-Gly-Arg-b-naphthylamide in mouse diaphragm. European Journal of Phar ma cology 343: 51-56 .
  •  Lin MJ and Lin-Shiau SY (1997) Multiple types of Ca2+ channels at the mouse motor nerve terminals. European Journal of Neuroscience. 9: 817-823 (1997).
  •  Liu SH, Lai JL, Lin RH, Lin MJ and Lin-Shiau SY (1997) Involvement of nitric oxide in the in vivo effects of lipopolysaccharide on the contractile and electrical properties of mouse diaphragm.        Naunyn-Schmiedeberg's Arch Phar ma col.356:500-504 .
  •  Lin MJ and Lin-Shiau SY (1996) Ruthenium Red, a novel enhancer of K+ currents at mouse motor nerve terminals. Neurophar ma cology 35: 615-623.
  •  Lin MJ and Lin-Shiau SY (1995) Functional assessment of Ca2+-current in the mouse motor nerve terminals. Neuroscience Letter 195: 21-24.
  •  Lin-Shiau SY, Liu SH and Lin MJ (1993) Use of ion channel blockers in the exploration of possible mechanisms involved in the myopathy of diabetic mice. Naunyn-Schmiedeberg Arch. Phar ma col. 348: 311-318. 

(B):研討會論文 

  • Jing-Jer Chen, Jiann-Jou Yang, Min-Jon Lin (2009). Functional study of phosphatase inhibitors on KCNQ4 potassium channel. The 24th Joint Annual Conference of Biomedical Sciences. No. P187, p250 (abstract).
  • Po-Yu Lu, Ya-Fang Teng, Ruey-Hseng Lin, Min-Jon Lin (2008). The study of the effect of nitric oxide on the voltage-dependent K+ current of outer hair cell in guinea pig cochlea. The 23th Joint Annual Conference of Biomedical Sciences. No. P180, p228 (abstract).
  • Ren-Yu Huang, Kuang-Ming Hsiao, Min-Jon Lin*.(2007) Functional Study of the Phosphorylation site of Hu ma n CLCN1 by Protein Kinase C. Taiwan Proteomics Society International Conference 2007 (TPSIC2007). No. P001, page 42. (abstract).
  • Chen K.-Y., Chiang S.-Y., Lin Min-Jon., Wu Y.-C., and Hsiao K.-M. (2003) Developmentally regulated effects of expanded CTG repeats on gene expression and neuromuscular function in Caenorhabditis elegans. Symposium on Recent Advances in Cellular and Molecular Biology () p116 (P-106).
  • Chiang S.-Y., Li Y.-Y., Lin Min-Jon., Wu Y.-C., Pan H., and Hsiao K.-M. (2002) Pathogenic effects of expanded CUG repeat in transgenic C. elegans. Symposium on Recent Advances in Cellular and Molecular Biology () p43 (A10).
  • Lin Min-Jon and Lin-Shiau SY. Effects of phorbol esters on transmitter release from motor terminals in b-bungarotoxin in vivo treated preparations. The Thirteenth Joint Annual Conference of Biomedical Sciences. No. P73, p161. ,1999 (abstract)
  • Lin Min-Jon and Lin-Shiau SY. Evidence for antagonism on nicotinic acetylcholine receptor by a tripeptide CBZ-Gly-Gly-Arg-b-naphthylamide in mouse diaphragm. The Twelfth Joint Annual Conference of Biomedical Sciences. No. P73, p161. ,1998 (abstract)
  • Chen YS, Lin Min-Jon and Lin-Shiau SY. Alteration of ion channels in the mouse diaphragm induced by chronic administration of b-bungarotoxin. The Eleventh Joint Annual Conference of Biomedical Sciences. No. P73, p161. ,1996 (abstract).
  • Lin Min-Jon, Tai TY and Lin-Shiau SY. Reversal by probucol of resistance to hydrogen peroxide in reducing Na+ conductance of mouse motor nerve on the diabetic mice. The Tenth Joint Annual Conference of Biomedical Sciences. No. 397, p173., 1995. (abstract)
  • Lin Min-Jon and Lin-Shiau SY. Increase susceptibility to inhibition by lidocaine, verapamil and nicardipine in the diabetes motor nerve. The Ninth Joint Annual Conference of Biomedical Sciences. No. 318, p97. ,1994 (abstract).
  • Lin Min-Jon, Liu SH and Lin-Shiau SY. Studies on the decrease of membrane Cl- conductance induced by Cd2+ and phorbol ester in the mouse diaphragm. The Eighth Joint Annual Conference of Biomedical Sciences. No. 207, p62. ,1993 (abstract).