
陳威仁 副教授
(Dr. Wei-Jen Chen)

Tel:(04)2473-0022
ext 11808;12308
Fax:(04)2324-8187

EDUCATION:
博士:台灣大學醫學院生化暨分子生物學研究所,2000 ~ 2004
碩士:私立長庚醫學暨工程學院基礎醫學研究所,1995 ~ 1997
學士:國立陽明大學醫事技術學系檢驗組,1991 ~ 1995
EXPERIENCE:
現職:
中山醫學大學 生物醫學科學學系 副教授 2010.8 ~迄今
經歷:
中山醫學大學生命科學系助理教授,2005.8 ~2010.7
台灣大學醫學院生化暨分子生物學研究所博士後研究員,2004.8 ~ 2005.7
國軍八Ο三總醫院(國軍台中總醫院)醫檢科醫檢師,1998.7 ~ 1999.6

(A):研究方向
1. 茶多酚之抗癌機制研究
2. 以蛋白質體學方法系統性分析茶多酚作用蛋白
(B):研究計畫
98年度:紫檀氏抗發炎及抗腫瘤增生作用機制之探討(2/3)
(國科會 97-2320-B-040-015-MY3)
97年度:紫檀氏抗發炎及抗腫瘤增生作用機制之探討(1/3)
(國科會 97-2320-B-040-015-MY3)
96年度:以化學性蛋白質體學方法分析EGCG結合蛋白並評估其在化學癌症預防之重要性
(國科會 96-2320-B-040-023)
95年度:以化學蛋白質體學方法分析茶紅素對蛋白酵素體抑制作用之選擇性
(國科會 NSC 95-2320-B-040-037-)
94年度:兒茶素EGCG抑制腫瘤相關性脂肪酸合成酵素機制之研究
(國科會 NSC 94-2312-B-040-001-)
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細胞與分子生物學
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基因工程
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普通生物學
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分子生物學實驗

(A):期刊論文
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Pan,M. H., Lin, C. L., Tsai, J. H., Ho, C. T. and Chen, W. J.* (2010). 3,5,3’,4’,5’-Pentamethoxystilbene (MR-5), a Synthetically Methoxylated Analogue of Resveratrol, Inhibits Growth and Induces G1 Cell Cycle Arrest of Human Breast Carcinoma MCF-7 Cells. Journal of Agricultural and Food Chemistry. Vol. 58, pp. 226-234.
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Lin, J. N., Lin, V. C., Rau, K. M., Shieh, P. C., Kuo, D. H., Shieh, J. C., Chen, W. J., Tsai, S. C. and Way, T. D.* (2010). Resveratrol Modulates Tumor Cell Proliferation and Protein Translation via SIRT1-Dependent AMPK Activation. Journal of Agricultural and Food Chemistry. Vol. 58, pp. 1584-1592.
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Pan, M. H., Lin, Y. T., Lin, C. L., Wei, C. S., Ho, C. T. and Chen, W. J.* (2009). Suppression of Heregulin-β1/HER2-Modulated Invasive and Aggressive Phenotype of Breast Carcinoma by Pterostilbene via Inhibition of Matrix Metalloproteinase-9, p38 Kinase Cascade and Akt Activation. Evidence-based Complementary and Alternative Medicine. Epub ahead of print: eCAM Advance Access published on Jul 16, 2009; doi:10.1093/ecam/nep093.
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Pan, M. H., Chiou, Y. S., Chen, W. J., Wang, J. M., Bad
ma ev, V., Ho, C. T. (2009). Pterostilbene inhibited tumor invasion via suppressing multiple signal transduction pathways in hu
ma n hepatocellular carcino
ma cells. Carcinogenesis. Vol. 30, pp. 1234-1242 (SCI)
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Chen, W. J., Huang, Y. T., Wu, M. L., Huang, T. C., Ho, C. T. and Pan, M. H.* (2008). Induction of apoptosis by vitamin D2, ergocalciferol, via reactive oxygen species generation, glutathione depletion, and caspase activation in hu
ma n leukemia Cells. Journal of Agriculture and Food Chemistry. Vol. 56, pp. 2996-3005 (SCI)
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Pan, M. H., Lin, C. C., Lin, J. K. and Chen, W. J.* (2007). Tea polyphenol EGCG suppresses heregulin-β1-induced fatty acid synthase expression in hu
ma n breast cancer cells by inhibiting PI3K/Akt and MAPK cascade signaling. Journal of Agriculture and Food Chemistry. Vol. 55, pp. 5030-5037 (SCI)
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Chen, W. J. and Lin, J. K. (2004). Induction of G1 arrest and apoptosis in hu
ma n Jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and el
eva ting p27Kip1, p21Cip1/WAF1 and Bax proteins. The Journal of Biological Chemistry, Vol. 279, pp. 13496-13505 (SCI)
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Chen, W. J. and Lin, J. K. (2004). Mechanisms of cancer chemoprevention by hop bitter acids (beer aro
ma ) through induction of apoptosis mediated by Fas and caspase cascades. Journal of Agriculture and Food Chemistry, Vol. 52, pp. 55-64 (SCI)
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Chen, W. J., Chang, C. Y. and Lin, J. K. (2003). Induction of G1 phase arrest in MCF-7 hu
ma n breast cancer cells by pentagalloylglucose through the down-regulation of CDK4 and CDK2 activities and up-regulation of the CDK inhibitors p27Kip and p21Cip. Biochemical Phar
ma cology, Vol. 65, pp. 1777-1785 (SCI)
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Yeh, C. W., Chen, W. J., Chiang, C. T., Lin-Shiau, S. Y. and Lin, J. K. (2003). Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. Phar
ma cogenomics Journal, Vol. 3, pp. 267-276 (SCI)
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Ho, L. L., Chen, W. J., Lin-Shiau, S. Y. and Lin, J. K. (2002). Penta-O-galloyl-beta-D-glucose inhibits the invasion of mouse melano
ma by suppressing metalloproteinase-9 through down-regulation of activator protein-1. European Journal of Phar
ma cology, Vol. 23, pp. 1677-1684 (SCI)
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Pan, M. H., Chen, W. J., Lin-Shiau, S. Y., Ho, C. T. and Lin, J. K. (2002). Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as el
eva ting Cdk inhibitors p21 and p27 in hu
ma n colorectal carcino
ma cells. Carcinogenesis, Vol. 453, pp. 149-158 (SCI)
(B) 研討會論文
- Wei, C. S. and Chen, W. J.* (2009). Effects of pterostilbene on heregulin-β1-associated signal transduction of hu
ma n breast cancer cells. 第二十四屆生物醫學聯合學術年會.
- Tsai, J. H. and Chen, W. J.* (2009). Studies on the molecular mechanisms of 3,5,3',4',5'-pentamethoxystilbene induced G1 cell cycle arrest in MCF-7 hu
ma n breast cancer cells. 第二十四屆生物醫學聯合學術年會.
- Lin, Y. T. and Chen, W. J.* (2008). Suppression of inducible nitric oxide synthase in lipopolysaccharides-activated
ma crophages by pterostilbene. Sixteen symposium on recent advances in cellular and molecular biology. 第16屆細胞及分子生物新知研討會.
- Lin, C. C. and Chen, W. J.* (2007). Study on the mechanisms by which EGCG inhibits heregulin-β1-induced Fas expression. 第二十二屆生物醫學聯合學術年會.
- Chen, W. J.* (2006). Mechanisms by which (-)-epigallocatechin 3-gallate inhibits heregulin-beta1-induced fatty acid synthase expression in breast cancer cell lines. 232nd ACS National Meeting & Exposition.
- Lin, J. K., Chen, W. J. and Lin-Shiau, S. Y. (2005). Pentagalloylglucose induces G1 arrest and apoptosis through suppressing proteasome activity and el
eva ting Cdk inhibitors and Bax proteins in hu
ma n Jurkat T cells. Am
eric an Association for Cancer research, 96th Annual Meeting.
- Chen, W. J. and Lin, J. K. (2005). Mechanisms by which (-)-epigallocatechin 3-gallate inhibits heregulin-β1-induced fatty acid synthase expression in breast cancer cell lines. Am
eric an Association for Cancer research, 96th Annual Meeting.
- Chen, W. J. and Lin, J. K. (2003). Induction of G1 arrest in hu
ma n Jurkat T cells by pentagalloylglucose through inhibiting proteasome activity and el
eva ting p27Kip1 and p21Cip1/WAF1. 第十八屆生物醫學聯合學術年會.
- Chen, W. J. and Lin, J. K. (2002). Induction of apoptosis by α-
ma ngostin in hu
ma n leukemia HL-60 cells. 第十七屆生物醫學聯合學術年會.
(C) 專書
- Pan, M. H. and Chen, W. J.* (2008) ACS Books "Functional Food and Health.": The cancer preventive potential of tea polyphenol EGCG in HER2-positive breast cancer. 2008 pp. 335-344
- Pan, M. H., Chen, W. J., Lo, C. H., Li, S., Sang, S., and Ho, C. H. (2008) ACS Books "Functional Food and Health.": Induction of apoptosis by acetylated black tea polyphenol through reactive oxygen species production, cytochrome c release, and caspase activation in hu
ma n leukemia HL-60 cells. 2008 pp. 345-361