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 劉玉凡 副教授



(Dr. Yu-Fan Liu)





Tel:(04)2473-0022 ext 11819;12370









1987-1991 Department of Agricultural Chemistry, National Taiwan University, Taiwan. Degree awarded: B.Sc. (台大農化系, 學士)

1991-1993 Institute of Biochemistry National Taiwan University, Taiwan. Degree awarded: M.Sc. (台大生化所, 碩士)

1998-2005 Institute of Biochemistry National Yang-Ming University, Taiwan. Degree awarded: Ph.D. (陽明生化所, 博士)

Professional and Academic Experiences:

2011-present Associated Professor, Department of Biomedical Science, Chung Shan Medical University, Taiwan (中山醫學大學生物醫學科學學系, 副教授)

2006-2011 Assistant professor, Department of Biomedical Science, Chung Shan Medical University, Taiwan (中山醫學大學生物醫學科學學系, 助理教授)

2003-2006 Adjunct assistant professor, Department of Biotechnology Ming-Chuan University, Taiwan (銘傳大學生物科技學系, 兼任助理教授)

2003-2006 Project Investigator, TaiGen Biotechnology Company, Taiwan (太景生物科技公司, 副研究員)

1995-1998 Associate Research Scientist, National Center for High-Performance Computing, Taiwan (國家高速電腦中心, 助理研究員)

Research Experiences

2003-2006 Structural bioinformatics-based drug design

a. Bioinformatics approaches for Design of anti-SARS Drugs. (2003)

b. Structures-based SARS Coronavirus Drugs Discovery.(2004)

c. Bioinformatics approaches for Design of anti-HCV Drugs (2004)

d. Approaching a new era for hepatitis C virus therapy. (2004)

e. The function of MMP proteases in HCV entry (2004)

f. The function analysis of HCV envelope proteins in virus entry. (2004)

g. Structure-based Anti-Cancer drug design (2005) 


2012/08/01 ~ 2013/07/31

"探討真菌免疫調節蛋白的醣類結合模組在誘發人類周邊單核球細胞產生干擾素γ作為減緩氣喘之健康食品的應用", 國科會計畫, NSC 101-2320-B-040-011-

2012/08/01 ~ 2013/07/31

"口蹄疫胜肽疫苗的設計與研發", 產學計畫, 蓁豪有限公司

2012/01/01 ~ 2012/12/31

"氣喘減敏生物藥劑之研究", 校內計畫, 中山醫學大學附設醫院

2011/01/01 ~ 2011/12/31

"研究真菌類免疫調節蛋白質之免疫調節活性重要胜肽區段與誘導IFN-γ傳訊作用機制", 校內計畫, 中山醫學大學附設醫院

2010/01/01 ~ 2010/12/31

"Regulation of Interference-gamma by the Immunomodulatory protein from Flammulina velutipe", 校內計畫, 中山醫學大學附設醫院

2010/08/01 ~ 2012/07/31

"以生物資訊學的方法對於FMDV疫苗B細胞誘發胜肽的設計與研發", 產學計畫, 翼碩生技股份有限公司

2010/01/01 ~ 2010/12/31

"Region wide association fine-map of chr.4q25 identifies ALPK1, a novel gout susceptibility gene in Taiwan aborigines", 校外合作計畫, 高雄醫學大學環境醫學頂尖中心

2007/08/01 ~ 2008/7/31

"探討MBNL蛋白質調控選擇性剪接的分子機轉", 國科會新進人員計畫, NSC 96-2311-B-040-002

2006/12/1 ~ 2007/07/31

"離子通道磷酸化功能的探討", 國科會新進人員計劃, NSC 95-2321-B-040-009-



1. 與陽明大學楊永正教授 於國家高速電腦中心開辦Bioinformatics training courses. July.1997-Feb.1998

a. 初級班:序列分析入門

b. 中級班:參數設定與數據解釋

c. 高級班:基因體序列分析

2. 財團法人自強工業基金會的授課課程

a. Mapping informatics - March.2001

b. Disease gene discovery - Apr.2001

c. Proteomics studies 1 - Future works in the post genomic era. June.2001

d. Proteomics studies 2 - Computer-aided drug design. June.2001

e. 生物資訊工具 - Apr.2004

3. 台灣大學 – 暑期生物技術訓練課程

a. Database search - Oct.2002

4. 銘傳大學生物課技系 - 整學期授課課程

a. 程式設計(Perl Programming) Sep.2003-Jan.2004, Sep.2004-Jan.2005

b. 生物資訊 – Feb.2004-Jun.2004, Feb.2005-present

5. 陽明大學生物資訊所 – 協助授課課程

a. Special Topics in Bioinformatics, 2004 Feb.2004 Apr.2004

6. 成功大學 – 協助授課課程

a. 生物技術暑期共同核心課程 - 生物資訊理論與實務應用, 2004-2006

7. 嘉義大學 – 協助授課課程. 應用微生物系 - 生物技術及實習

a. Genome informatics for disease approach (2004)

b. 生物資料庫搜尋生物巨分子結構實作 (2004)

c. Bioinformatics approaches in Post-Genome Era (2005) 



(A): 期刊論文

  1. Y.F.Liu , C.T. Liao, W.L. Song and P.C. Hsu, Y.M, Hsiao* (2012) “GsmR, a response regulator with a histidine-aspartate-related output domain in Xanthomonas campestris, is positively controlled by Clp and involved in cell motility and the expression of genes responsible for flagellum synthesis.”  FEBS Journal (accepted) – SCI [Impact factor: 3.790; Ranking: 89/290, BIOCHEMISTRY & MOLECULAR BIOLOGY] 
  2. C.C Su, Y.F. Liu, S.Y. Li, J.J. Yang* and Y.C. Yen (2012) “Mutations in the CYP1B1 gene may contribute to juvenile-onset open-angle glaucoma.” Eye 26(10), 1369-1377 – SCI [Impact factor: 1.851; Ranking: 23/56, OPHTHALMOLOGY] 
  3. C.W. Cheng, Y.F. Liu, J.C. Yu, H.W. Wang, S.L. Ding, C.N. Hsiung, H.M. Hsu, P.E. Wu and C.Y. Shen (2012) “Prognostic Significance of cyclin D1, β-catenin, and MTA1 in Patients with Invasive Ductal Carcinoma of the Breast.” Ann Surg. Oncol. 19(13), 4129-4139 – SCI  [Impact factor: 4.166; Ranking: 9/199, SURGERY] 
  4. Y.F. Liu, S.H. Chang, H.L. Sun, Y.C. Chang, K.H. Lue and J.L. Ko* (2012) “IFN-γ Induction on Carbohydrate Binding Module of Fungal Immunomodulatory Protein in Human Peripheral Mononuclear Cells.” Journal of Agricultural and Food Chemistry 60(19), 4914-4922 – SCI [Impact factor: 2.823; Ranking: 3/57, AGRICULTURE, MULTIDISCIPLINARY] 
  5.  Y.T. Tee, Y.F. Liu, J.T. Chang, S.F. Yang, S.C. Chen, P.H. Wang and C.L. Liao (2012) “Single-Nucleotide Polymorphisms and Haplotypes of Membrane Type 1-Matrix Metalloproteinase in Susceptibility and Clinical Significance of Squamous Cell Neoplasia of Uterine Cervix in Taiwan Women” Reproductive Sciences 19(9): 932-938 – SCI [Impact factor: 2.444; Ranking: 18/79 (OBSTETRICS & GYNECOLOGY)] 
  6. C.H. Hu, Y.F. Liu, J.S. Yu, Y.Y. Ng, S.J. Chen, P.H. Su and J.Y. Chen (2012) “A MID1 gene mutation in a patient with Opitz G/BBB syndrome that altered the 3D structure of SPRY domain” American Journal of Medical Genetics 158A(4): 726-731 – SCI [Impact factor: 2.391; Ranking: 91/158 (GENETICS & HEREDITY)] 
  7. P.H. Su, Y.F. Liu, J.S. Yu, J.Y. Chen, S.J. Chen and Y.J. Lai* (2012) “Facial asymmetry and clinical manifestations in patients with novel insertion of the TCOF1 gene.” Clinical Genetics 82(5): 460-645 – SCI [Impact factor: 3.128; Ranking: 68/158, GENETICS & HEREDITY] 
  8. Y.M. Hsiao*, Y.F. Liu, P.Y. Lee, P.C. Hsu, S.Y. Tseng and Y.C. Pan (2011) “Functional characterization of copA gene encoding multicopper oxidase in Xanthomonas campestris pv. campestris.” Journal of Agricultural and Food Chemistry 59(17), 9290-9302 – SCI [Impact factor: 2.823; Ranking: 3/57, AGRICULTURE & MULTIDISCIPLINARY] 
  9. T.Y. Chen, Y.C. Li, Y.F. Liu, C.M. Tsai, Y.H. Hsieh, C.W. Lin, S.F. Yang and C.J. Wang* (2011) “ Role of MMP14 gene polymorphisms in susceptibility and pathological development to hepatocellular carcinoma” Annals of Surgical Oncology 18(8), 2348-2356 – SCI [Impact factor: 4.166; Ranking: 9/199, SURGERY] 
  10. W.H. Wang, Y.F. Liu, C.C. Su, M.C. Su, S.Y. Li and J.J. Yang* (2011) “A novel missense mutation in the connexin30 causes nonsyndromic hearing loss.” PLoS One 6(6): e21473 – SCI [Impact factor: 4.092; Ranking: 12/85, BIOLOGY] 
  11. S.C. Tang, M.F. Wu, R.H. Wong, Y.F. Liu, L.C. Tang, C.H. Lai, C.P. Hsu and J.L. Ko* (2011) “Epigenetic mechanisms for silence of Glutathione Stransferase M2 expression by hypermethylated Sp1 binding in lung cancer” Cancer 117(14), 3209-3221 – SCI [Impact factor: 4.771; Ranking: 36/196, ONCOLOGY] 
  12. Y.M. Hsiao*, Y.F. Liu, M.C. Fang and W.L. Song (2011) “XCC2731, a GGDEF domain protein in Xanthomonas campestris, is involved in bacterial attachment and is positively regulated by Clp” Microbiological Research 166(7), 548-565 – SCI [Impact factor: 2.308; Ranking: 62/114, MICROBIOLOGY] 
  13. Y.M. Hsiao*, Y.F. Liu, Y.L. Huang and P.Y. Lee (2011) “Transcription analysis of pmeA gene encoding a pectin methylesterase in Xanthomonas campestris pv. Campestris” – Research in Microbiology 162(3), 270-278 – SCI [Impact factor: 2.763; Ranking: 48/114, MICROBIOLOGY] 
  14. P.H. Wang, Y.F. Liu, H.T. Tsai, Y.T. Tee, L.Y. Lin, Y.H. Hsieh and S.F. Yang* (2010) “Elevated Plasma Osteopontin Level is Associated With Pelvic Inflammatory Disease” Reproductive Sciences. 17(11): 1052-1058 – SCI  [Impact factor: 2.444; Ranking: 18/79 (OBSTETRICS & GYNECOLOGY)] 
  15. C.Y. Feng, P.H. Wang, H.T. Tsai, J.L. Ko, S.C. Chen, C.Y. Lin, C.P. Han, J.S. Yang, Y.F. Liu, L.Y. Lin and S.F. Yang* (2010) “Polymorphisms of Human Nonmetastatic Clone 23 Type 1 Gene and Neoplastic Lesions of Uterine Cervix” Reproductive Sciences 17(10): 886-893 – SCI  [Impact factor: 2.444; Ranking: 18/79 (OBSTETRICS & GYNECOLOGY)] 
  16. P.H. Wang, Y.C. Yi, H.T. Tsai, Y.T. Tee, J.L. Ko, C.P. Han, Y.F. Liu, L.Y. Lin and S.F. Yang* (2010) “Significant association of genetic polymorphism of human nonmetastatic clone 23 type 1 gene with an increased risk of endometrial cancer” Gynecologic Oncology 119(1): 70-75 – SCI [Impact factor: 3.888; Ranking: 4/79 (OBSTETRICS & GYNECOLOGY)]
  17. C.J. Weng, C.M. Tsai, Y.C. Chen, Y.H. Hsieh, C.W. Lin, Y.F. Liu, S.C. Su, M.K. Chen and S.F. Yang* (2010) “Evaluation of the association of urokinase plasminogen activator system genes polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma” Annals of Surgical Oncology 17(12): 3394-3401 – SCI [Impact factor: 4.166; Ranking: 9/199 (SURGERY)]
  18. M.Y. Lan, Y.F. Liu, S.J. Lin, Y.F. and Chen, C.H*. (2010) "Cavernous Malformations of the Central Nervous System Combined with Vascular Cutaneous Lesions due to KRIT1 Mutation: A Case Report" Clinical Neurology and Neurosurgery 112(8) : 729-732 – SCI [Impact factor: 1.581; Ranking: 80/199 (SURGERY)]
  19. M.Y. Lan, M.H. Fu, Y.F. Liu, Y.Y. Chang, J.S. Liu, C.H. Peng and S.S. Chen* (2010) “High frequency of ETFDH c.250G>A Mutation in Taiwanese Patients with Late-Onset Lipid Storage Myopathy” Clinical Genetics 78(6) : 565-569 – SCI [Impact factor: 3.128; Ranking: 58/158 (GENETICS & HEREDITY)]
  20. P.C. Hsiao, M.K. Chen, S.C. Su, K.C. Ueng, Y.C. Chen, Y.H. Hsieh, Y.F. Liu, H.T. Tsai, S.F. Yang* (2010) “Hypoxia Inducible Factor-1α Gene Polymorphism G1790A and Its Interaction with Tobacco and Alcohol Consumptions Increase Susceptibility to Hepatocellular Carcinoma” Journal of Surgical Oncology : 102(2) 163-169 – SCI [Impact factor: 2.100; Ranking: 56/199 (SURGERY)]
  21. Y.M. Hsiao*, Y.F. Liu, M.C. Fang and Y.H. Tseng (2010) “Transcriptional Regulation and Molecular Characterization  of manA Gene Encoding the Biofilm Dispersing Enzyme Mannan Endo-1,4-β- mannosidase in Xanthomonas campestris” Journal of Agricultural and Food Chemistry 58(3), 1653-1663 – SCI [Impact factor: 2.823; Ranking: 3/57, AGRICULTURE & MULTIDISCIPLINARY]
  22. C.J. Weng, Y.H. Hsieh, C.M. Tsai, Y.H. Chu, K.C. Ueng, Y.F. Liu, A. I Zavras, S.C. Su, Y.C. Chen, M.K. Chen, S.F. Yang* (2010) “Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma” Annals of Surgical Oncology 17(7)– 1808-1815 - SCI [Impact factor: 4.166 ; Ranking: 9/199 (SURGERY)]
  23. M.Y. Lan, S.J. Lin, Y.F. Chen, C.H. and Y.F. Liu* (2009) “A novel missense mutation of the SMPD1 gene in a Taiwanese patient with type B Niemann–Pick disease.” Ann. Hematol. 88(7): 695-697, 2009 – SCI [Impact factor: 2.615 ; Ranking: 33/68 (HEMATOLOGY)]
  24. Y.F. Liu, Liu, H.Y., Tu, L.C., Lin C.W., Hsiao, K.M. and Pan, H.* (2008) “Zebrafish muscleblind-like genes: Identification, structural features and expression.” Comparative Biochemistry and Physiology, Part B 151(1), 118-124. – SCI (NSC 96-2311-B-040-002) [Impact factor: 1.923; Ranking: 24/145 (ZOOLOGY)]
  25. Wang L.C., Hung W.T., Pan H., Chen K.Y., Wu Y.C., Y.F. Y.F. Liu, Hsiao K.M.* (2008) “Growth-dependent effect of muscleblind knockdown on Caenorhabditis elegans.” Biochemical and biophysical research communications 366(3) : 705-709 – SCI [Impact factor: 2.484; Ranking: 39/74 (BIOPHYSICS)]
  26. S. Yang, S.J. Chen, M.F. Hsu, J.D. Wu C. K. Tseng, Y. F. Liu, H.C. Chen, C.W. Kuo, and C.S. Wu et.al. (2006) “Synthesis, Crystal Structure, Structure-Activity Relationships, and Antiviral Activity of a Potent SARS Coronavirus 3CL Protease Inhibitor” J.Med.Chem. 49(16), 4971-4980 – SCI [Impact factor: 5.248 ; Ranking: 3/59, CHEMISTRY, MEDICINAL]

  27. Y. F. Liu and U. C. Yang* (2004) “SCAdb: A candidate gene database for spinocerebellar ataxia.” Bioinformatics 20(16): 2656-2661. – SCI [Impact factor: 5.468 ; Ranking: 15/158 (BIOTECHNOLOGY & APPLIED MICROBIOLOGY)]

  28. 劉玉凡生物資訊學在藥物開發的應用生物產業 13 (第一期) 379-387 (2002)

  29. 劉玉凡揭開電子鼻的奧秘,科學月刊 385 32-35 (2002)

  30.  Y. F. Liu and Ta-Hsiu Liao* "Mechanism for Inhibition of Deoxyribonuclease Activity by Antiserum" J. Protein Chemistry 16(2) : 75-82 (1997) – SCI

  31. M.H. Lee, C.H. Tsai, Y.F. Liu, Y.J. Chang, N.T. Chen, C.C. Liao and C.C. Chen* "The Antitumor activity of Naphthoquinones isolated from stem of MARKHAMIA HILDEBRANDTH" J. Chinese Oncol. Soc. 7(2), 1-10, (1991) – SCI




(B): 專書及專書與研討會論文 

  1. C.H. Chang, A. Wang and Y.F. Liu ”In Silico Selection and Enhancement of Porcine T Helper Cell Epitopes for Peptide Vaccine Development” The 27th Joint Annual Conference of Biomedical Sciences (2012)
  2. S.Y. Liu and Y.F. Liu “In silico approach of CUGBP2-regulated alternative-spicing candidate genes determination” The 26th Joint Annual Conference of Biomedical Sciences (2011)
  3. Y.F. Liu, K.H. Lue and J.L. Ko “Carbohydrate Binding Module on Fungal Immunomodulatory Protein is Essential for IFN- induction in Human Peripheral Mononuclear Cells” The 26th Joint Annual Conference of Biomedical Sciences (2011)
  4. T.Y. Chang and Y.F. Liu “Genome-wide analysis for alternative splicing regulation by MBNL-relative proteins” RNA Symposium 2010.
    S.Y. Liu, T.Y. Chang and Y.F. Liu “Characterizing the alternative splicing of novel genes regulated by zmbnl1 in zebrafish embryonic development” SCMB Symposium 2010
  5. Genome informatics: applications in disease gene and novel gene discovery” Y. F. Liu, Ph.D Thesis. (2005)
  6. Y. F. Liu (2004) ASM Conference on Functional Genomics and Bioinformatics Approaches to Infectious Disease Research - Symposium
  7. Y. F. Liu and Din-Lii Lin (2003) 15th AACR-EORTC international Conference on Molecular Targets and Cancer Therapeutics Discovery, Biology, and Clinical Applications - Symposium
  8. Y. F. Liu and Ueng-Cheng Yang. (2003) SCA db: Spinocerebellar ataxia candidate gene database. Bioinformatics In Taiwan 2003 (BIT2003) symposium - Poster.
  9. Y. F. Liu and Ueng-Cheng Yang. (2002) Phylogenetic Analysis of Domains. 16PthP Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) symposium - Poster
  10. Lu, W-F., Y. F. Liu, Yang, U-C., Hsu, W-L. (2001) A tolerant map construction program that can use the EST markers to improve map construction. RECOMB Satellite Meeting on DNA Sequence Assembly.
  11. Y. F. Liu, Yu-Huei Liao, and Ueng-Cheng Yang, Genome-wide Motif Scanning. The Fifth Annual International Conference On Computational Molecular Biology (2001) - Poster
  12. Y. F. Liu, Y.C. Chang, S.P. Shen, Y.H. Liao and U.C. Yang. Bioinformatics study of Unc5-related genes in human. The Sixteenth Joint Annual Conference of Biomedical Sciences (2001) – Symposium
  13. Y. F. Liu, Bing-Wen Soong and Ueng-Cheng Yang. (2000) “Bioinformatics study of Spinocerebella Ataxia genes.” The second Brook-Top symposium, the Chinese Society for Biochemistry and Molecular Biology - Poster
  14. Y. F. Liu, Y.-H Liao, Y.-C Chang, U.-C Yang. (2000) Bioinformatics study of trinucleotide repeats related diseases. The Fifteenth Joint Annual Conference of Biomedical Sciences - Oral
  15. Y. F. Liu, Yu-Chung Chang, Yu-Hwei Liao, Yan-Yuan Tsen and Ueng-Cheng Yang. (2000) An Integrated Software for Human Genome Annotation. Eighth Symposium on Recent Advances in Cellular and Molecular Biology - Poster