Tsu-Shing Wang

(Professor; Ph. D)

 

Phone

Tel:886-4-2473-0022 ext 12313
 

E-mail

tsushing@csmu.edu.tw

 

 

 

 

 

 

 

 

Interests in Research

My research interests are focused upon two main areas: (1) to understand the molecular mechanism(s) of arsenite-, cigarette smoke extract- or methylglyoxal- induced DNA damages (oxidized DNA bases and DNA-protein crosslinks) and carbonylated proteins in mammalian cells and (2) to screen the Chinese herbal medicine with potential of anti-diabetes activity in an in vitro protein glycation system in order to confirm their possible molecular mechanism(s) that contribute to their antidiabetic actions.
 

Publications (at most 7 publications in recent 5 years)

1. Yu-HaoHe, Ming-HsinYeh, Hsiao-FanChen, Tsu-Shing Wang, Ruey-HongWong et. al.,ERα determines the chemo-resistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions Molecular Therapy - Nucleic Acids 2021; : -.(SCI)
2. Chia-Han Tsai, Chong-Kuei Lii, Tsu-Shing Wang, Kai-Li Liu, Haw-Wen Chen, Chin-Shiu Huang, Chien-Chun Li,Docosahexaenoic acid promotes the formation of autophagosomes in MCF-7 breast cancer cells through oxidative stress-induced growth inhibitor 1 mediated activation of AMPK/mTOR pathway Food Chem Toxicol . 2021 Aug;154:112318. doi: 10.1016/j.fct.2021.112318. Epub 2021 Jun 8. 2021; : -.(SCI)
3. Tian ZH, Weng JT, Shih LJ, Siao AC, Chan TY, Tsuei YW, Kuo YC, Wang TS, Kao,Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways. PLoS One 2018; 13(7): 1-19.(SCI)
4. Wang TS, Lin CP, Chen YP, Chao MR, Li CC, Liu KL,CYP450-mediated mitochondrial ROS production involved in arecoline N-oxide-induced oxidative damage in liver cell lines. Environ Toxicol 2018; 33: 1029-1038.(SCI)
5. Lee JS, Lin YY, Wang TS, Liu JY, Lin WW, Yang JJ,Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK Chin J Physiol 2018; 61(1): 25-34.(SCI)
6. Wu YL, Chang JC, Lin WY, Li CC, Hsieh M, Chen HW, Wang TS, Wu WT, Liu CS, Liu ,Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway. Free Radic Biol Med 2018; 115: 309-317.(SCI)
7. Lee JS, Wang TS, Lin MC, Lin WW, Yang JJ,Inhibition of Curcumin on ZAKαActivity Resultant in Apoptosis and Anchorage-Independent Growth in Cancer Cells. Chin J Physiol 2017; 60(5): 267-274.(SCI)
8. Wu YL, Chang JC, Lin WY, Li CC, Hsieh M, Chen HW, Wang TS, Liu CS, Liu KL,Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3. Scientific Report 2017; : -.(SCI)
9. Huang YC, Tsai MS, Hsieh PC, Shih JH, Wang TS, Wang YC, Lin TH, Wang SH.,Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling. Toxicol Appl Pharmacol 2017; 329: 128-139.(SCI)
10. Hu CW, Chang YJ, Hsu YW, Chen JL, Wang TS, Chao MR.,Comprehensive analysis of the formation and stability of peroxynitrite-derived 8-nitroguanine by LC-MS/MS: Strategy for the quantitative analysis of cellular 8-nitroguanine. Free Radic Biol Med 2016; 101: 348-355.(SCI)
11. Lii CK, Chang JW, Chen JJ, Chen HW, Liu KL, Yeh SL, Wang TS, Liu SH, Tsai CH, Li CC,Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13- acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKCδ- and Wnt-1/β-catenin-mediated pathways. Oncotarget 2016; 7: 2516-2517.(SCI)
12. Lii CK, Chang JW, Chen JJ, Chen HW, Liu KL, Yeh SL, Wang TS, Liu SH, Tsai CH, Li CC,Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13- acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKCδ- and Wnt-1/β-catenin-mediated pathways Oncotarget 2016; 7: 2516-2517.(SCI)
13. Lin BH, Tsai MH, Lii CK, Wang TS,IP3 和鈣離子訊號參與香菸煙霧提取物在人類內皮細胞的肌動蛋白重組及細胞圓形化 環境毒理學 2015; 31(11): 1293-1306.(SCI)