Wei-Jen Chen

(Associate Professor; Ph. D)

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Interests in Research

Our research focuses on exploring the mechanisms of action of resveratrol derivatives against breast cancer cell proliferation, metastasis and epithelial-mesenchymal transition. We found that resveratrol structural derivatives, 3,5,3,4,5'-pentamethoxystilbene, were able to inhibit cell cycle progression of human breast cancer cell line MCF-7, and also demonstrated that another resveratrol structural analogue, 3,5,4'-trimethoxystilbene, inhibited epithelial-mesenchymal transition and the following invasion of MCF-7 cells. These studies provide the molecular basis for designing a new lead drug for breast cancer based on the structure of resveratrol..
 

Publications (at most 7 publications in recent 5 years)

1. Ching‐Chi Chang, Sing‐Hua Tsou, Wei‐Jen Chen, Ying‐Jui Ho, Hui‐Chih Hung , Guang‐Yaw Liu, Sandeep Kumar Singh, Hsin‐Hua Li and Chih‐Li Lin,miR-302 Attenuates Mutant Huntingtin-Induced Cytotoxicity through Restoration of Autophagy and Insulin Sensitivity International Journal of Molecular Sciences 2021; 2021(22): 8424-8437.(SCI)
2. Wei-Jen Chen*, Jie-Heng Tsai, Li-Sung Hsu, Chih-Li Lin, Hui-Mei Hong and Min-Hsiung Pan*,Quercetin Blocks the Aggressive Phenotype of Triple Negative Breast Cancer by Inhibiting IGF1/IGF1R-Mediated EMT Program Journal of Food and Drug Analysis 2021; 29: 98-112.(SCI)
3. Kuei-Yang Han, Pei-Ni Chen, Ming-Chian Hong, You-Cheng Hseu, Ke-Ming Chen, Li-Sung Hsu, Wei-Jen Chen*,Naringenin Attenuated Prostate Cancer Invasion via Reversal of Epithelial-to-Mesenchymal Transition and Inhibited uPA Activity. Aanticancer Research. Anticancer Research 2018; 38: 6753-6758.(SCI)
4. 2. Ddy Konelius, Hsin-Hua Li, Chiung-Huei Peng, Wei-Jen Chen, Yan-Zin Chang, Yi-Chao Bai, Stanley Liu, Chein-Ning Huang, and Chih-Li Lin,Liraglutide protects against glucolipotoxicity-induced RIN-m5F β-cell apoptosis through restoration of PDX1 expression. Journal of Cellular and Molecular Medicine 2018; 23: 619-629.(SSCI)
5. Ching-Chi Chang, Tzu-Chin Lin, Hsiao-Li Ho, Chien-Yin Kuo, Hsin-Hua Li, Tatiana A. Korolenko, Wei-Jen Chen, Te-Jen Lai, Ying-Jui Ho*, and Chih-Li Lin*,GLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin Signaling International Journal of Molecular Sciences 2018; 19: 2505-2518.(SCI)
6. Jie-Heng Tsai, Li-Sung Hsu, Hsiu-Chen Huang, Chih-Li Lin, Min-Hsiung Pan, Hui-Mei Hong, and Wei-Jen Chen,1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione induces G1 cell cycle arrest and autophagy in HeLa cervical cancer cells. International Journal of Molecular Sciences 2016; 17: 2174-2188.(SCI)
7. 2. Kuei-Yang Han, Maw-Soan Soon, Ming-Chian Hong, Chia-Cheng Kuo, Shih-Chan Lai, Ke-Ming Chen, Chih-Jung Chen, Kun-Tu Yeh, Li-Sung Hsu, Wei-Jen Chen*,Naringenin attenuated prostate cancer invasion via reversed epithelial to mesenchymal transition and inhibited urokinase plasminogen activator activities Experimental and Therapeutic Medicine 2016; : -.(SCI)
8. James Cheng-Chung Wei, Hsiu-Chen Huang, Wei-Jen Chen, Chien-Ning Huang, Chiung-Huei Peng, and Chih-Li Lin,Epigallocatechin gallate attenuates amyloid β-induced inflammation and neurotoxicity in EOC 13.31 microglia European Journal of Pharmacology 2015; 770: 16-24.(SCI)
9. Wai-Fai Tung, Wei-Jen Chen, Hui-Chih Hung, Guang-Yaw Liu, Jai-Nien Tung, Chien-Chih Huang, and Chih-Li Lin,4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen-Glucose Deprivation (OGD) and Reoxygenation. Cellular and Molecular Neurobiology 2015; 35: 849-859.(SCI)