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Wen-Wei Chang

(Professor; Ph. D)

 

Phone

Tel(Office):886-4-2473-0022 ext 12305
Tel(Lab):886-4-2473-0022 ext 11701
 

E-mail

changww@csmu.edu.tw
 


 

 

 

 

 

 

 

 

Interests in Research

Cancer stem cells (CSCs) are a particular sub-population of cells within cancers/tumors. CSCs have been demonstrated to be associated with tumor initiation, chemoresistance, radioresistance and metastasis of cancers. To target CSCs is an emerging research area in cancer research and cancer therapy. Our interests are focus on the signal transduction of maintenance pathways, such as epithelial-mesenchymal transition, Wnt/beta-catenin or c-Myc, in CSCs of breast cancer, endometrial cancer, lung cancer, oral squamous carcinoma. We are recently working on the involvement of TRIB3 (Tribbles homolog 3) or immune checkpoint molecules in the maintenance CSCs. We also interest in searching the CSC-targeting natural compounds, such as plant phytochemicals, Chinese herb extracts or probiotics extracts, and study their molecular mechanisms.

Publications (at most 7 publications in recent 5 years)

  1. Wang BY, Shen HT, Lee YL, Chien PJ, Chang WW,Inhibition of Na+/H+ exchanger (NHE) 7 by 5-(N-ethyl-N-isopropyl)-Amiloride displays anti-cancer activity in non-small cell lung cancer by disrupting cancer stem cell activity and downregulating PD-L1 expression. Am J Cancer Res 2023; : -.(SCI)
  2. Huei-Fan Yang, Wen-Wei Chang, Ying-Hsiang Chou, Jing-Yang Huang, Ya-Fang Ke, Pei-Fang Tsai, Hsiu-Man Chan, Hsueh-Ya Tsai, Hsien-Chun Tseng, Shih-Tsung Chang & Yueh-Chun Lee,Effectiveness of multimedia courses in improving self-care among patients with breast cancer undergoing radiotherapy Radiation Oncology 2023; 18: 115-.(SCI)
  3. Tsai1 WH, Fang TY, HuangTY, Chiang YJ, Lin CG, Chang WW,Heat-killed Lacticaseibacillus paracasei GMNL-653 ameliorates human scalp health by regulating scalp microbiome BMC Microbiology 2023; 23: 121-.(SCI)
  4. Lin EK, Chang WW, Jhong JH, Tsai WH, Chou CH, Wang IJ.,Lacticaseibacillus paracasei GM-080 Ameliorates Allergic Airway Inflammation in Children with Allergic Rhinitis: From an Animal Model to a Double-Blind, Randomized, Placebo-Controlled Trial Cells 2023; 12(5): 76-94.(SCI)
  5. Chang WW, Wang BY, Chen SH, Chien PJ, Sheu GT, Lin CH,miR-145-5p Targets Sp1 in Non-Small Cell Lung Cancer Cells and Links to BMI1 Induced Pemetrexed Resistance and Epithelial-Mesenchymal Transition Int J Mol Sci 2022; 23(23): 1535-.(SCI)
  6. Wen-Ling Wang, Shih-Ming Chen, Yueh-Chun Lee, Wen-Wei Chang,Stigmasterol inhibits cancer stem cell activity in endometrial cancer by repressing IGF1R/mTOR/AKT pathway Journal of Functional Foods 2022; 99: 1053-.(SCI)
  7. Ni YL, Chien PJ, Hsieh HC, Shen HT, Lee HT, Chen SM, Chang WW,Disulfiram/Copper Suppresses Cancer Stem Cell Activity in Differentiated Thyroid Cancer Cells by Inhibiting BMI1 Expression Int J Mol Sci 2022; 23: 1327-.(SCI)
  8. Tsai WH, Chou CH, Huang TY, Wang HL, Chien PJ, Chang WW, Lee HT,Heat-Killed Lactobacilli Preparations Promote Healing in the Experimental Cutaneous Wounds Cells 2021; 10(11): 3264-.(SCI)
  9. Liu YH, Li YL, Shen HT, Chien PJ, Sheu GT, Wang BY, Chang WW. ,L-Type Amino Acid Transporter 1 Regulates Cancer Stemness and the Expression of Programmed Cell Death 1 Ligand 1 in Lung Cancer Cells Int. J. Mol. Sci. 2021; 22(20): 1095-.(SCI)
  10. Jun-Ren Dong, Wen-Wei Chang, Shih-Ming Chen,Nerolidol inhibits proliferation of leiomyoma cells via reactive oxygen species-induced DNA damage and downregulation of the ATM/Akt pathway Phytochemistry 2021; 191: 1129-1129.(SCI)
  11. Ta-Chin Lin, I-Ling Hsu, Wan-Hua Tsai, Yi-Chih Chu, Lung-Ching Kuan, Min-Syuan Huang, Wen-Ling Yeh, Ya-Hui Chen, Shan-Ju Hsu, Wen-Wei Chang,Improvement of bacterial vaginosis by oral Lactobacillus supplement: a randomized, double-blinded trial Applied Sciences 2021; 11(3): 902-.(SCI)
  12. Wang WL, Hong GC, Chien PJ, Huang YH, Lee HT, Wang PH, Lee YC, Chang WW.,Tribbles Pseudokinase 3 Contributes to Cancer Stemness of Endometrial Cancer Cells by Regulating β-Catenin Expression Cancers 2020; 12(12): 3785-.(SCI)
  13. Lin LC, Lee HT,Chien PJ, Huang YH,Chang MY, Lee YC, Chang WW,NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1 Int J Med Sci 2020; 17(14): 2214-2224.(SCI)
  14. Shen HT, Chien PJ, Chen SH, Sheu GT, Jan MS, Wang BY, Chang WW,BMI1-Mediated Pemetrexed Resistance in Non-Small Cell Lung Cancer Cells Is Associated with Increased SP1 Activation and Cancer Stemness Cancers 2020; 12(8): 2069-.(SCI)
  15. Bing Yen Wang, Yen-Cheng Lin, Yi-Ting Lai, Jia-Yu Ou, Wen-Wei Chang, Chih-Chien Chu,Targeted Photoresponsive Carbazole–Coumarin and Drug conjugates for Efficient Combination Therapy in Leukemia Cancer Cells Bioorganic Chemistry 2020; 100: 1039-1039.(SCI)
  16. Hui-Ying Low1, Yueh-Chun Lee, Yi-Ju Lee, Hui-Lin Wang, Yu-I Chen, Peng-Ju Chien, Shao-Ti Li, Wen-Wei Chang,Reciprocal regulation between Indoleamine 2,3-dioxigenase 1 and Notch1 involves in radiation response of cervical cancer stem cells Cancers 2020; 12(6): 1547-.(SCI)
  17. Chan YT, Lai AC, Lin RJ, Wang YH, Wang YT, Chang WW, Wu HY, Lin YJ, Chang WY, Wu JC, Yu JC, Chen YJ, Yu AL,GPER-induced signaling is essential for the survival of breast cancer stem cells Int J Cancer 2020; 146(6): 1674-1685.(SCI)
  18. Kuo MH, Chang WW, Yeh BW, Chu YS, Lee YC, Lee HT,Glucose transporter 3 is essential for the survival of breast cancer cells in the brain Cells 2019; 8(12): 1568-1581.(SCI)
  19. Wattanakul K, Imae T, Chang W, Chu C, Nakahata R, Yusa S,Oligopeptide-side chained alginate nanocarrier for melittin-targeted chemotherapy Polymer Journal 2019; 51: 771-780.(SCI)
  20. YC Lee, WL Wang, WC Chang, YH Huang, GC Hong, HL Wang, YH Chou, HC Tseng, HT Lee, ST Li, HL Chen, CC Wu, HF Yang, BY Wang, WW Chang,Tribbles homolog 3 involves in radiation response of triple negative breast cancer cells by regulating Notch-1 activation Cancers 2019; 11(2): 127-141.(SCI)
  21. YH Chen, WH Tsai, HY Wu, CY Chen, WL Yeh YH Chen, HY Hsu, WW Chen, YW Chen, WW Chang, TL Lin, HC Lai, YH Lin, CH Lai ,Probiotic Lactobacillus spp. act Against Helicobacter pylori-induced Inflammation Journal of Clinical Medicine 2019; 8(1): 90-.(SCI)
  22. Yu-Jen Lee, Wen-Wei Chang, Chien-Ping Chang, Tsung-Yun Liu, Chun-Yi Chuang, Kun Qian, Y. George Zheng, Chuan Li,Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells Scientfic Reports 2018; 9: 1171-.(SCI)
  23. Ming-Chia Hsieh, Wan-Hua Tsai, Yu-Pang Jheng, Shih-Li Su, Shu-Yi Wang, Chi-Chen Lin, Yi-Hsing Chen, Wen-Wei Chang,The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial Scientific Reports 2018; 8: 1679-.(SCI)
  24. Chih-Jen Yang, Wen-Wei Chang, Song-Tao Lin, Man-Chin Chen, Che-Hsin Lee�x,Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation International Journal of Medical Sciences 2018; 15(6): 574-579.(SCI)
  25. Shih-Ming Chen, Bing-Yen Wang, Che-Hsin Lee, Hsueh-Te Lee, Jung-Jung Li, Guan-Ci Hong, Yu-Chieh Hung, Peng-Ju Chien, Che-Ying Chang, Li-Sung Hsu, Wen-Wei Chang,Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells Oncotarget 2017; 8: 7605-7606.(SCI)
  26. Lin HC, Yang CJ, Kuan YD, Wang WK, Chang WW, Lee CH.,The inhibition of indoleamine 2, 3-dioxygenase 1 by connexin 43 International Journal of Medical Sciences 2017; 14: 1181-1188.(SCI)
  27. Yueh-Chun Lee, Wen-Wei Chang, Yi-Ying Chen, Yu-Hung Tsai, Ying-Hsiang Chou, Hsien-Chun Tseng, Hsin-Lin Chen, Chun-Chieh Wu, Ju Chang-Chien, Hsueh-Te Lee, Huei-Fan Yang, Bing-Yen Wang,Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2 International Journal of Molecular Sciences 2017; 18: 1986-1998.(SCI)
  28. Bing-Yen Wang, Ming-Liang Liao, Guan-Ci Hong, Wen-Wei Chang *, Chih-Chien Chu*,Near-infrared-triggered photodynamic therapy toward breast cancer cells using dendrimer-functionalized upconversion nanoparticles Nanomaterials 2017; 7(9): 269-286.(SCI)
  29. Chuang CY, Chang CP, Lee YJ, Lin WL, Chang WW, Wu JS, Cheng YW, Lee H, Li C,PRMT1 expression is elevated in head and neck cancer and inhibition of protein argining methylation by adenosine dialdehyde or PRMT1 knockdown downregulate proliferation and migration of oral cancer cells Oncology Reports 2017; 38(2): 1115-1123.(SCI)
  30. Lee YC, Chang HW, Tseng HC and Chang WW,Analysis of Prognostic and Related Factors in Hepatocellular Carcinoma Patients with Portal Vein Thrombosis after Radiotherapy Austin J Cancer Clin Res 2016; 3: 1070-1074.(其他)
  31. Jui-Hung Weng, Yueh-Chun Lee, Cheng-Chia Yu, Cheng-Wei Lin, Wen-Wei Chang, Yu-Liang Kuo,miR-494-3p induces cellular senescence and enhances radiosensitivity in human oral squamous carcinoma cells International Journal of Molecular Sciences 2016; 17: 1092-1101.(SCI)
  32. Dom-Gene Tu, Wen-Wei Chang, Song-Tao Lin, Chun-Yu Kuo, Yu-Tzu Tsao, and Che-Hsin Lee,Salmonella inhibits tumor angiogenesis by downregulation of vascular endothelial growth factor Oncotarget 2016; 7(25): 3751-3752.(SCI)
  33. Tu DG, Chang WW, Jan MS, Tu CW, Lu YC, Tai, CK,Promotion of metastasis of thyroid cancer cells via NRP-2-mediated induction Oncology Letters 2016; 12(5): 4224-4230.(SCI)
  34. Kaun-Ta Lu, Bing-Yen Wang, Wan-Yu Chi, Ju Chang-Chien, Jiann-Jou Yang, Hsueh-Te Lee, Yew-Min Tzeng, Wen-Wei Chang,Ovatodiolide inhibits breast cancer stem/progenitor cells through SMURF2 mediated downregulation of Hsp27 Toxins 2016; 8(5): E127-.(SCI)
  35. Lee YC, Yu CC, Lan C, Lee CH, Lee HT, Kuo YL, Wang PH, Chang WW,Plasminogen activator inhibitor-1 regulates tumor initiating cell properties in head and neck cancers Head and Neck 2016; Suppl 1: E895-E904.(SCI)
  36. Chang YC, Lin CW, Yu CC, Wang BY, Huang YH, Hsieh YC, Kuo YL, Chang WW,Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression Oncotarget 2016; 7: 1213-1214.(SCI)
  37. Wang WK, Lin ST, Chang WW, Liu LW, Li TY, Kuo CY, Hsieh JL, Lee CH,Hinokitiol induces autophagy in murine breast and colorectal cancer cells Environmental Toxicology 2016; 31: 77-86.(SCI)
  38. Che-Hsin Lee, Cheng-Chia Yu, Bing-Yen Wang, and Wen-Wei Chang,Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs Oncotarget 2015; 7: 1215-1226.(SCI)
  39. Cheng YJ, Chang MY, Chang WW, Wang WK, Liu CF, Lin ST, Lee CH,Resveratrol enhances chemosensitivity in mouse melanoma model through connexin 43 upregulation Environmental Toxicology 2015; 30: 877-886.(SCI)
  40. Lee CH, Wu YT, Hsieh HC, Yu Y, Yu AL, Chang WW.,Epidermal growth factor/heat shock protein 27 pathway regulates vasculogenic mimicry activity of breast cancer stem-like/progenitor cells Biochimie 2015; 104: 117-126.(SCI)
  41. Hung CH, Chang WW, Liu SC, Wu SJ, Chu CC, Tsai YJ, Imae T.,Self-aggregation of amphiphilic [60]fullerenyl focal point functionalized PAMAM dendrons into pseudodendrimers: DNA binding involving dendriplex formation Journal of Biomedical Materials Research Part A 2015; 103: 1595-1604.(SCI)
  42. Tu DG, Yu Y, Lee CH, Kuo YL, Lu YC, Tu CW, ChangWW,Hinokitiol inhibits vasculogenic mimicry activity of breast cancer stem/prgenitor cells through proteasome-mediated degradation of epidermal growth factor receptor Oncology Letters 2015; 11: 2934-2940.(SCI)

最後更新日期

2024-04-25