張文瑋 教授

Dr. Wen-Wei Chang

學歷:

• 2006.05 博士 國立成功大學基礎醫學研究所 病毒免疫學
• 1999.06 學士 國立成功大學 生物學系

經歷:

• 2019.08~present 中山醫學大學 生物醫學科學學系 教授
• 2017.08 ~ 2019.07  中山醫學大學 生物醫學科學學系 教授兼系主任
• 2017.11~ 2019.11  台灣幹細胞協會 秘書長
• 2015.08 ~ 2017.07 中山醫學大學 生物醫學科學學系 教授
• 2012.08 ~ 2015.07 中山醫學大學 生物醫學科學學系 副教授
• 2009.08 ~ 2012.07 中山醫學大學 生物醫學科學學系 助理教授
• 2006.07 ~ 2009.07 中央研究院 基因體研究中心 博士後研究員
• 1999.09 ~ 2006.05 成功大學醫學院 基礎醫學研究所 博士生研究助理

專長及教授課程:

• 腫瘤生物學
• 幹細胞醫學
• 分子醫學

研究方向及計畫:

• 實驗室研究方向著重於癌症幹細胞的生物學，以乳癌、肺癌、口腔癌以及子宮內膜癌為對象，試圖了解調控癌症幹細胞的訊息傳遞網路。另外，也試圖從天然萃取物中尋找能夠抑制癌症幹細胞的潛力分子，並了解其作用機轉。近年來也開始進行產學合作，協助廠商進行產品抗菌功效測試及調節免疫功能測試，以及協助以癌症幹細胞為平台進行腫瘤疫苗優化。

過去與目前正在進行的研究計畫

• 105年度探討TRIB3/Notch訊號對乳癌細胞抗放射線治療的分子機制
• 105年度乳癌幹細胞內熱休克90蛋白調控EZH2表現的機制探討
• 105年度熱休克蛋白27 與其磷酸化對於乳癌幹細胞之維持的影響（3/3）
• 105年度功能性益生菌系列產品進行研究測試計畫
• 106年度探討副乾酪乳桿菌(Lactobacillus paracasei strain 346)抑制口腔癌細胞增生的分子機制
• 106年度科技部計畫  免疫檢查哨分子在癌幹細胞之非免疫調節活性的功能性探討 (多年期)
• 106年度 產學計畫  益生菌(Lactobacillus reuteri ADR-1 及ADR-3)改善二型糖尿病之相關研究及功效資料整理 (景岳生物科技)
• 107年度科技部計畫   Tribbles Pseudokinase 3參與子宮內膜癌惡化機制與透過扁柏醇達到抑制效果的研究 (多年期)
• 107年度竹科「研發精進計畫」(產學合作計畫)  癌幹細胞表面抗原之抗癌療效檢測平台開發 (世福細胞醫學)
• 108年科技部計畫免疫檢查哨分子在癌幹細胞之非免疫調節活性的功能性探討(2/3)
• 108年探討光敏潛力材料對乳癌細胞毒殺的分子機制
• 108年抑制口腔癌之功效益生菌開發計畫
• 108年科技部計畫Tribbles Pseudokinase 3參與子宮內膜癌惡化機制與透過扁柏醇達到抑制效果的研究 (2/3)
• 108年科技部計畫免疫檢查哨分子在癌幹細胞之非免疫調節活性的功能性探討 (3/3)
• 109年科技部計畫Tribbles Pseudokinase 3參與子宮內膜癌惡化機制與透過扁柏醇達到抑制效果的研究(3/3）
• 109年 益生菌改善慢性阻塞性肺病(COPD)之相關研究及功效

期刊論文:(近五年代表著作)

• Li-Ching Lin, Hsueh-Te Lee, Peng-Ju Chien, Yu-Hao Huang, Mu-Ya Chang , Yueh-Chun Lee ,   Chang WW.NAD(P)H:quinone oxidoreductase 1 determines radiosensitivity of triple negative breast cancer cells and is controlled by long non-coding RNA NEAT1. Int J Med Sci. 2020;17(14):2214-2224.
• Huan-Ting Shen, Peng-Ju Chien, Shih-Hong Chen, Gwo-Tarng Sheu, Ming-Shiou Jan, Bing-Yen Wang, Chang WW.BMI1-Mediated Pemetrexed Resistance in Non-Small Cell Lung Cancer Cells Is Associated with Increased SP1 Activation and Cancer Stemness.Cancers (Basel). 2020;12(8):2069. 
• Bing-Yen Wang, Yen-Cheng Lin, Yi-Ting Lai, Jia-Yu Ou,  Chang WW , Chih-Chien Chu  .Targeted Photoresponsive Carbazole–Coumarin and Drug conjugates for Efficient Combination Therapy in Leukemia Cancer Cells.Bioorg Chem. 2020;100:103904.
• Hui-Ying Low, Yueh-Chun Lee, Yi-Ju Lee, Hui-Lin Wang, Yu-I Chen, Peng-Ju Chien, Shao-Ti Li, Chang WW .Reciprocal Regulation Between Indoleamine 2,3-Dioxigenase 1 and Notch1 Involved in Radiation Response of Cervical Cancer Stem Cells.Cancers (Basel). 2020 ;12(6):1547.
• Yu-Tzu Chan, Alan C-Y Lai, Ruey-Jen Lin, Ya-Hui Wang, Yi-Ting Wang,Chang WW , Hsin-Yi Wu, Yu-Ju Lin, Wen-Ying Chang, Jen-Chine Wu, Jyh-Cherng Yu, Yu-Ju Chen, Alice L Yu .GPER-induced signaling is essential for the survival of breast cancer stem cells. Int J Cancer . 2020.15;146(6):1674-1685.
• Min-Hsun Kuo,Chang WW, Bi-Wen Yeh, Yeh-Shiu Chu, Yueh-Chun Lee, Hsueh-Te Lee .Glucose transporter 3 is essential for the survival of breast cancer cells in the brain.Cell.2019 ;8(12):1568.
• Karnthidaporn Wattanakul, Toyoko Imae,Chang WW , Chih-Chien Chu, Rina Nakahata & Shin-ichi Yusa Oligopeptide-side chained alginate nanocarrier for melittin-targeted chemotherapy. Polymer Journal.2018. 51:771–780.
• Lee YC, Wang WL, Chang WC, Huang YH, Hong GC, Wang HL, Chou YH, Tseng HC, Lee HT, Li ST, Chen HL, Wu CC, Yang HF, Wang BY, Chang WW. Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation. Cancers (Basel). 2019. 11(2). pii: E127.
• Hsieh MC, Tsai WH, Jheng YP, Su SL, Wang SY, Lin CC, Chen YH, Chang WW. The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial. Sci Rep. 2018. 8(1):16791.
• Chen SM, Wang BY, Lee CH, Lee HT, Li JJ, Hong GC, Hung YC, Chien PJ, Chang CY,Hsu LS, Chang WW. Hinokitiol up-regulates miR-494-3p to suppress BMI1 expression and inhibits self-renewal of breast cancer stem/progenitor cells. Oncotarget. 2017. 8(44):76057-76068.
•  Lee YC*, Chang WW*, Chen YY, Tsai YH, Chou YH, Tseng HC, Chen HL, Wu CC,Chang-Chien J, Lee HT, Yang HF, Wang BY. Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2. Int J Mol Sci. 2017. 18(9). pii: E1986. * Contributed equally.
• Wang BY, Liao ML, Hong GC, Chang WW*, Chu CC*. Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles. Nanomaterials (Basel). 2017. 7(9). pii: E269. * Corresponding authors.
• Lu KT, Wang BY, Chi WY, Chang-Chien J, Yang JJ, Lee HT, Tzeng YM, Chang WW.Ovatodiolide Inhibits Breast Cancer Stem/Progenitor Cells through SMURF2-Mediated Downregulation of Hsp27. Toxins (Basel). 2016. 8(5). pii: E127.
• Lee YC, Yu CC, Lan C, Lee CH, Lee HT, Kuo YL, Wang PH, Chang WW. Plasminogen activator inhibitor-1 as regulator of tumor-initiating cell properties in head and neck cancers. Head Neck. 2016. 38 Suppl 1:E895-904.

研討會議論文:

• Lan C, Yu CC, Chang YC, Chang WW. The role of plasminogen activator inhibitor-1 in oral cancer stem cells. The 27th Joint Annual Conference of Biomedical Sciences. 2012. Taipei, Taiwan. (Poster Presentation, No. 010).
• Lai YL, Yu CC, Chang YC, Chang WW. The role of arecoline in the myofibroblast differentiation from normal oral fibroblasts and keratinocytes. The 8th Asia Pacific Symosium on Neural Regeration in conjunction with The 5th Pan Pacific Symposium on Stem Cells and Cancer Research. 2012. Taipei, Taiwan (Poster Presentation, No. PG-3)
• Chang WW, Lee CH, Hong HM, Chang YY. Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. 22nd Biennial Congress of the European Association for Cancer Research. 2012. Barcelona. Spain. (Poster Presentation, No. 112)
• Lee CH, Wu YT, Hsieh HC, Yu Y, Yu AL, Chang WW. Epidermal growth factor/heat shock protein 27 pathway regulates vasculogenic mimicry activity of breast cancer stem-like/progenitor cells. The 18th International Vascular Biology Meeting. 2014. Kyoto. Japan. (Poster Presentation, No. LB-15).
• Chang WW, Chang-Chien J, Yang JJ, Tzang BS, Hsu TC. Influences of zebrafish embryo development by human parvovirus B19- NS1 and VP1u protein. 7th Zebrafish Disease Models Conference. 2014. Madison. USA. (Poster Presentation, No. 135)