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王祖興 教授

Dr. Tsu-Shing Wang


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Tel:(04)2473-0022 ext 11811;12313

tsushing@csmu.edu.tw

 

 

學歷:

  • 國立清華大學輻射生物學博士

 

經歷:

  • 中山醫學大學教授 主秘及圖資長2017.8~迄今
  • 中山醫學大學教授及醫科院院長 2010.8~2017.7
  • 中山醫學大學教授及系主任 2009.8~2010.7
  • 中山醫學大學副教授2005.6~2010.7
  • 中山醫學大學助理教授1997.9~2005.6
  • 中山醫學大學教務處綜合服務組組長
  • 法國居禮研究院博士後研究

 

專長及教授課程:

  • 細胞生物學
  • 普通生物學
  • 核酸轉錄調節機制

 

研究方向及計畫:

  • 104年度：檳榔鹼及其氧化物之代謝與毒性作用機制探討(科技部)
  • 103年度：香菸煙霧水提取物誘導細胞內鈣離子濃度增加和微絲骨架重組的分子調控：蛋白激?C、磷脂?C及微絲動態調節蛋白質的角色(科技部)
  • 102年度：食品中致癌性亞硝胺之快速篩檢與暴露危害評估(科技部)
  • 102年度：香菸煙霧水提取物造成人類血管內皮細胞及斑馬魚幼蟲發炎特性及保健防治研究(科技部)
  • 101年度：香菸煙霧水提取物造成人類血管內皮細胞及斑馬魚幼蟲發炎特性及保健防治研究(科技部)
  • 100年度：香煙萃物誘發ICAM-1基因增加表現之分子機制及防治研究 (國科會)
  • 99年度：香煙萃物誘發ICAM-1基因增加表現之分子機制及防治研究 (國科會 )
  • 98年度：香煙萃物誘發ICAM-1基因增加表現之分子機制及防治研究 (國科會)
  • 96年度：生地黃、葛根、黨蔘、北耆及天花粉熱水提取物在糖尿病合併症保健功效之探勘 (國科會 )
  • 95年度：香煙萃物在人類臍靜脈內皮細胞造成膜上E-selection及ICAM-1表達增加之分子機制探討 (國科會)
  • 94年度：亞砷酸鈉及過氧化氫造成人類臍靜脈內皮細胞蛋白質羰基化：模式蛋白質及蛋白質體學探討 (國科會)
  • 93年度：台農二號山藥水萃取物保肝活性及可能分子機制之探討 (國科會)
  • 91年度：山藥水萃物銅離子螯合活性有效分子確認及對銅離子代謝異常相關疾病保健功效之評估
  • 89年度：山藥抽取物質抗氧化活性及其對哺乳動物細胞氧化性傷害可能之保護角色

 

期刊論文:

  1. Zi-Han Tian, Jueng-Tsueng Weng, Li-Jane Shih, An-Ci Siao, Tsai-Yun Chan, Yi-Wei Tsuei, Yow-Chii Kuo,Wang TS, Yung-Hsi Kao 1Arecoline inhibits the growth of 3T3-L1 preadipocytes via AMP-activated protein kinase and reactive oxygen species pathways.PLoS One. 2018;13(7):e0200508.
  2. Wang TS, Cheng-Ping Lin, Yu-Pong Chen, Mu-Rong Chao, Chien-Chun Li, Kai-Li Liu.CYP450-mediated mitochondrial ROS production involved in arecoline N-oxide-induced oxidative damage in liver cell lines.Environ Toxicol.2018;33(10):1029-1038.
  3. Jin-Sun Lee, Yuh-Yih Lin, Wang TS,  Jer-Yuh Liu, Wei-Wen Lin, Jaw-Ji Yang . Antitumorigenic Effects of ZAKβ, an Alternative Splicing Isoform of ZAK.Chin J Physiol.2018 ;61(1):25-34.
  4. Yu-Ling Wu, Jui-Chih Chang, Wei-Yong Lin, Chien-Chun Li ,Mingli Hsieh ,Haw-Wen Chen, Wang TS, Wen-Tzu Wu, Chin-San Liu, Kai-Li Liu. Caffeic acid and resveratrol ameliorate cellular damage in cell and Drosophila models of spinocerebellar ataxia type 3 through upregulation of Nrf2 pathway.Free Radic Biol 2018;115:309-317.
  5. Lee JS, Wang TS, Lin MC, Lin WW, Yang JJ. Inhibition of curcumin on ZAKα activity resultant in apoptosis and anchorage-independent growth in cancer cells. Chin J Physiol. 2017; 60(5):267-274
  6. Wu YL, Chang JC, Lin WY, Li CC, Hsieh M, Chen HW, Wang TS, Liu CS, Liu KL. Treatment with Caffeic Acid and Resveratrol Alleviates Oxidative Stress Induced Neurotoxicity in Cell and Drosophila Models of Spinocerebellar Ataxia Type3. Sci Rep. 2017; 7(1):11641. doi: 10.1038/s41598-017-11839-0.
  7. Hu CW, Chang YJ, Hsu YW, Chen JL, Wang TS, Chao MR. Comprehensive analysis of the formation and stability of peroxynitrite-derived 8-nitroguanine by LC-MS/MS: Strategy for the quantitative analysis of cellular 8-nitroguanine. Free Radic Biol Med. 2016; 101:348-355.
  8. Lin BH, Tsai MH, Lii CK, Wang TS*. IP3 and calcium signaling involved in the reorganization of the actin cytoskeleton and cell rounding induced by cigarette smoke extract in human endothelial cells. Environ Toxicol. 2016; 31(11):1293-1306.
  9. Chen HW, Huang CS, Li CC, Lin AH, Huang YJ, Wang TS, Yao HT, Lii CK. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. Toxicol Appl Pharmacol. 2014; 280(1):1-9.

  10. Lii C.K., Chang J.W., Chen J.J., Chen H.W., Liu K.L., Yeh S.L., Wang T.S., Liu S.H., Tsai C.H., Li C.C. 2016. Docosahexaenoic acid inhibits 12-O-tetradecanoylphorbol-13-acetate-induced fascin-1-dependent breast cancer cell migration by suppressing the PKCδ- and Wnt-1/β-catenin-mediated pathways. Oncotarget 7(18):25162-79. (SCI)

  11. Chen H.W., Huang C.S., Li C.C., Lin A.H., Huang Y.J., Wang T.S., Yao H.T., Lii C.K. 2014. Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats. Toxicol Appl Pharmacol 280(1):1-9. (SCI)

  12. Chen C.C., Huang C.H., Wu M.T., Chou C.H., Huang C.C., Tseng T.Y., Chang F.Y., Li Y.T., Tsai C.C., Wang T.S., Wong R.H. 2014. Multidrug resistance 1 gene variants, pesticide exposure, and increased risk of DNA damage. Biomed Res Int. [doi:10.1155/2014/965729]. (SCI).
  13. Tu CY, Chen YF, Lii CK, Wang TS*. Methylglyoxal induces DNA crosslinks in ECV304 cells via a reactive oxygen species-independent protein carbonylation pathway. Toxicol In Vitro. 2013;27(4):1211-9.
  14. Huang, C.S., Lii, C.K., Lin, A.H., Yeh, Y.W., Yao, H.T., Li, C.C., Wang, T.S., Chen, H.W. 2013. Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes. Arch Toxicol 87(1):167-78. (SCI)
  15. Chen, Y,F., Roan, H.Y., Lii, C.K., Huang, Y.C., Wang, T.S. 2011. Relationship between antioxidant and antiglycation ability of saponins, polyphenols, and polysaccharides in Chinese herbal medicines used to treat diabetes. J Medicinal Plants Res 5(11): 2322-2331. (SCI)
  16. Lii CK, Lin AH, Lee SL, Chen HW, Wang TS*. Oxidative modifications of proteins by sodium arsenite in human umbilical vein endothelial cells. Environ Toxicol. 2011; 26(5):459-71.
  17. Liu, W,Y., Wang, C.Y., Wang, T.S., Fellers, G.M., Lai, B.C., Kam, Y.C. 2011. Impacts of the herbicide butachlor on the larvae of a paddy field breeding frog (Fejervarya limnocharis) in subtropical Taiwan. Ecotoxicology 20(2):377-384. (SCI)
  18. Yu, A.L., Lu, C.Y., Wang, T.S., Tsai, C.W., Liu, K.L., Cheng, Y.P., Chang, H.C., Lii, C.K., Chen ,H.W. 2010. Induction of heme oxygenase 1 and inhibition of tumor necrosis factor alpha-induced intercellular adhesion molecule expression by andrographolide in EA.hy926 cells. J Agric Food Chem 58(13):7641-7648. (SCI)
  19. Lin, C.C., Su, T.H., Wang, T.S.  2009. Protein carbonylation in THP-1 cells induced by cigarette smoke extract via a copper-catalyzed pathway. Chem Res Toxicol 22(7):1232-1238. (SCI)
  20. Chen, H.W., Lii, C.K., Ku, H.J., Wang, T.S. 2009. Cigarette smoke extract induces expression of cell adhesion molecules in HUVEC via actin filament reorganization. Environ Mol Mutage 50(2): 96-104. (SCI)
  21. Wang, T.S.,  Lii, C.K.,  Chang, J.Y.,  Kuo, C.I, Chen, H.P. 2007. Anti-Fenton reaction activity of three taxa of water yam (Dioscorea alata L.). Internat J Food Sci Technol 42( 9):1107-1113.
  22. Lee, Y.C., Yang, V.C., Wang, T.S. 2007. Use of RAPD to detect sodium arsenite-induced DNA damage in human lymphoblastoid cells. Toxicology 239(1-2):108-115. (SCI)
  23. Kuo, C. F., Wang, T.S., Yang, P.L., Jao, Y.C. Lin, W.Y. 2006. Antioxidant Activity of Liquid-State Fermentation Products of Monascus pilosus Grown in Garlic-Containing Medium. J Food Sci 71(6): S456-S460. (SCI)

 

研討會議論文:

  • Chen YP, Chen PY, Liu KL, Wang TS. 2016. Mechanism of Calcium Mobilization and Actin Cytoskeleton Remodeling in Human Endothelial Cells Under Cigarette Smoke Extract Exposure. Abstract of 31th Joint Annual Conference of Biomedical Sciences, ROC
  • Lin BH, Wang TS. 2013. Mechanism of Cigarette Smoke Extrac-Induced Reorganization of the Actin Cytoskeleton in Human Endothelial Cells. Abstract of The 10th APACT Conference, Chiba, Japan.
  • Lin BH, Wang TS. 2012. Cigarette Smoke Extract Induced Actin Cytoskeleton Reorganization in Endothelial Cells. Abstract of 27th Joint Annual Conference of Biomedical Sciences, ROC
  • Chen YP, Wang TS. 2012. Cytotoxicity and Genotoxicity of Cigarette Smoke Extract on Human Osteoblastic U2-OS Cells. Abstract of 27th Joint Annual Conference of Biomedical Sciences, ROC
  • Lin CP, Wang TS. 2012. Cytotoxic, Genotoxic and Mutagenic Effects of Arecoline and Its Oxidative Metabolites on Rat Liver Clone 9 Cells. Abstract of 27th Joint Annual Conference of Biomedical Sciences, ROC
  • Huang CW, Wang TS. 2011. Inhibition of FPG/OGG1 Nuclease Activity by Arsenite, Methylglyoxal, and Cigarette Smoke Extract in vitro. Abstract of 26th Joint Annual Conference of Biomedical Sciences, ROC
  • Chen YF, Wang TS. 2010. Methylglyoxal-induced DNA-protein crosslinks in ECV304 Cells via a ROS-independent protein carbonylation pathway. The XII International Congress of Toxicology, Barcelona, Spain.
  • Lii, C.K., Lin, A.H., Lee, S.L., Chen, H.W., Wang, T.S. 2009. Oxidative modicifcation of proteins by sodium arsenite in hu ma n umbilical vwein endothelial cells. Abstract of 19th International congress of nutrition, Tailand.
  • Huang, Y.C., Chen, Y.F., Wang, T.S. 2009. Protective effects of traditional Chinese medicinal herbs against DNA da ma ge induced by oxidants in ECV304 cells. Abstract of 24th Joint Annual Conference of Biomedicals Science, R.O.C.
  • Roan, H.Y., Chen, Y.F., Hunag, Y.C., Wang, T.S. 2008. Antioxidant and antiglycation properties of aqueous extracts from traditional Chinese herbs in vitro. Abstract of 23th Joint Annual Conference of Biomedicals Science, R.O.C.
  • Lee, Y.C., Yang, V.C., Wang T.S. 2007. Detection of sodium arsenite-induced DNA da ma ge in lymphoblastoid cells. Abstract of 11th Internation Congress of Toxicology, .
  • Chang, Y.T., Su, T.H., Wang, T.S. 2007.Effect of superoxide dismutase or catalase overexpression on oxidant-induced Toxicity and protein carbonylation. Abstract of 22nd Joint Annual Conference of Biomedical Sciences, R.O.C
  • 李叔蓮、王祖興、李宗貴.2004.亞砷酸鈉誘發人類臍靜脈內皮細胞蛋白質氧化硝基化之探討：二維電泳分析. 中華民國營養學會第三十屆年會暨學術研討會。
  • 莊玉涵、王祖興、陳暉雯.2004.香煙萃取物對人類臍靜脈內皮細胞的氧畫傷害.中華民國營養學會第三十屆年會暨學術研討會。

 

專書及專書論文:

  • 王祖興(2006) 生物學實驗 (ISBN: 978-986-412-334-6), 高立圖書出版, pp105.
  • Wang, T.S., 1996. Cellular and molecular mechanisms of arsenite toxicity. Ph.D. Thesis.

 

 

最後更新日期

2025-05-08